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个人简介
My main research interest is to understand the genetic and molecular basis of liver disease, and to apply these discoveries to prevent, diagnose and treat more effectively liver disorders (both common and rare diseases), through the identification of novel biomarkers and the development of advanced precision medicine targeted therapeutic approaches. I also focused on the impact of dysmetabolism on the outcome of viral diseases, and on the role of altered iron metabolism in the pathogenesis of chronic degenerative conditions.
I use a variety of tools ranging from genomic studies in large cohorts of healthy individuals and patients with metabolic liver disease with extensive phenotypic characterization (the European Liver Biopsy Cohort and Italian EPIDEMIC cohort, and the Fondazione Genomic study, a population based cohort, and Liver Bible, a multi-OMICs characterized cohort of individuals with dysmetabolism I set up at the Fondazione Biobank), to human and molecular genetics with generation of in vitro multilineage 3D models of disease by genome editing, to understand how genetic variation leads to phenotypic manifestations.
In the iron field, I have contributed to establishing the role of body iron accumulation in the pathogenesis of metabolic and cardiovascular complications of insulin resistance, and I am contributing to evaluate the therapeutic utility of iron depletion and the modulation of iron pathways for the prevention of metabolic diseases.
During the last five years, I more robustly established the causal link between genetic variation influencing hepatic lipid metabolism alterations and the spectrum of progressive liver disease, including primary liver cancer, highlighting the role of carriage of rare genetic variants responsible for Mendelian disorders, and during the COVID-19 pandemia I contributed highlighting the first genetic determinants of the susceptibility to develop severe COVID-19.
I use a variety of tools ranging from genomic studies in large cohorts of healthy individuals and patients with metabolic liver disease with extensive phenotypic characterization (the European Liver Biopsy Cohort and Italian EPIDEMIC cohort, and the Fondazione Genomic study, a population based cohort, and Liver Bible, a multi-OMICs characterized cohort of individuals with dysmetabolism I set up at the Fondazione Biobank), to human and molecular genetics with generation of in vitro multilineage 3D models of disease by genome editing, to understand how genetic variation leads to phenotypic manifestations.
In the iron field, I have contributed to establishing the role of body iron accumulation in the pathogenesis of metabolic and cardiovascular complications of insulin resistance, and I am contributing to evaluate the therapeutic utility of iron depletion and the modulation of iron pathways for the prevention of metabolic diseases.
During the last five years, I more robustly established the causal link between genetic variation influencing hepatic lipid metabolism alterations and the spectrum of progressive liver disease, including primary liver cancer, highlighting the role of carriage of rare genetic variants responsible for Mendelian disorders, and during the COVID-19 pandemia I contributed highlighting the first genetic determinants of the susceptibility to develop severe COVID-19.
研究兴趣
论文共 665 篇作者统计合作学者相似作者
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Jeffrey V. Lazarus,Henry E. Mark,Alina M. Allen,Juan Pablo Arab,Patrizia Carrieri,Mazen Noureddin,William Alazawi,Naim Alkhouri,Saleh A. Alqahtani,Quentin M. Anstee,Marco Arrese,Ramon Bataller,Thomas Berg,Paul N. Brennan,Patrizia Burra,Graciela E. Castro-Narro,Helena Cortez-Pinto,Kenneth Cusi,Nikos Dedes,Ajay Duseja,Sven M. Francque,Amalia Gastaldelli,Hannes Hagstrom,Terry T. K. Huang,Dana Ivancovsky Wajcman,Achim Kautz,Christopher J. Kopka,Aleksander Krag,Philip N. Newsome,Mary E. Rinella,Diana Romero,Shiv Kumar Sarin,Marcelo Silva,C. Wendy Spearman,Norah A. Terrault,Emmanuel A. Tsochatzis,Luca Valenti,Marcela Villota-Rivas,Shira Zelber-Sagi,Joern M. Schattenberg,Vincent Wai-Sun Wong,Zobair M. Younossi
HEPATOLOGYno. 2 (2024): 502-523
Matteo Mureddu,Serena Pelusi,Luisa Ronzoni,Francesco Malvestiti,Vittoria Moretti, Hadi Eigadeh,Giorgio Soardo,Alessandro Federico,Francesco Paolo Russo,Anna Ludovica Fracanzani,Umberto Vespasiani-Gentilucci,Luca Miele,Elisabetta Bugianesi,Roberta D'Ambrosio,Salvatore Petta,Mirella Fraquelli,Daniele Prati,Luca Valenti
Journal of Hepatology (2024)
Cristiana Bianco,Serena Pelusi,Sara Margarita,Federica Tavaglione,Oveis Jamialahmadi,Francesco Malvestiti,Giulia Periti,Jessica Rondena,Melissa Tomasi,Rossana Carpani,Luisa Ronzoni,Matteo Vidali,Ferruccio Ceriotti,Mirella Fraquelli,Umberto Vespasiani-Gentilucci,Stefano Romeo,Daniele Prati,Luca Valenti
UNITED EUROPEAN GASTROENTEROLOGY JOURNALno. 3 (2024): 364-373
Huai Zhang,Giovanni Targher,Christopher D. Byrne,Seung Up Kim,Vincent Wai-Sun Wong,Luca Valenti,Myer Glickman,Jaime Ponce,Christos S. Mantzoros,Javier Crespo,Henning Gronbaek,Wah Yang,Mohammed Eslam,Robert J. Wong,Mariana Verdelho Machado,Ming-Lung Yu,Omar M. Ghanem,Takeshi Okanoue,Jun-Feng Liu,Yong-ho Lee,Xiao-Yuan Xu,Qiuwei Pan,Meili Sui,Amedeo Lonardo,Yusuf Yilmaz,Li-Yong Zhu,Christophe Moreno,Luca Miele,Monica Lupsor-Platon,Lei Zhao, Teresa LeAnn LaMasters,Robert G. Gish,Huijie Zhang,Marius Nedelcu,Wah Kheong Chan,Ming-Feng Xia,Fernando Bril,Jun-Ping Shi,Christian Datz,Stefano Romeo,Jian Sun, Dan Liu,Silvia Sookoian,Yi-Min Mao,Nahum Méndez-Sánchez,Xiao-Yan Wang,Nikolaos T. Pyrsopoulos,Jian-Gao Fan,Yasser Fouad,Dan-Qin Sun,Cosimo Giannini,Jin Chai,Ze-Feng Xia,Dae Won Jun, Guo-Jing Li,Sombat Treeprasertsuk, Ying-Xu Li,Tan To Cheung,Faming Zhang,George Boon-Bee Goh,Masato Furuhashi,Wai-Kay Seto,Hui Huang,Anna Di Sessa, Qing-Hong Li, Evangelos Cholongitas,Le Zhang, Themis Reverbel Silveira,Giada Sebastiani,Leon A. Adams,Wei Chen,Xiaolong Qi,Ivan Rankovic,Victor De Ledinghen, Wen-Jie Lv,Masahide Hamaguchi,Radwan Kassir,Dirk Müller-Wieland,Manuel Romero-Gomez,Ying Xu,Yi-Cong Xu,Shi-Yao Chen,Mohammad Kermansaravi,Mohammad Shafi Kuchay,Sander Lefere,Chetan Parmar,Gregory Y. H. Lip,Chun-Jen Liu,Fredrik Åberg,George Lau,Jacob George,Shiv Kumar Sarin,Jing-Ya Zhou,Ming-Hua Zheng
Hepatology Internationalpp.1-24, (2024)
Wen-Yue Liu,Li-You Lian,Huai Zhang,Sui-Dan Chen, Xin-Zhe Jin, Ni Zhang, Chen-Hui Ye, Wen-Ying Chen,George Goh Boon Bee,Fu-Di Wang,Luca Miele,Elena Corradini,Luca Valenti,Ming-Hua Zheng
Angelo Armandi,Tiziana Sanavia,Ramy Younes,Gian Paolo Caviglia,Chiara Rosso,Olivier Govaere,Antonio Liguori,Paolo Francione,Rocio Gallego-Duran,Javier Ampuero,Grazia Pennisi,Rocio Aller,Dina Tiniakos,Alastair Burt,Ezio David,Fabio Vecchio,Marco Maggioni,Daniela Cabibi,Duncan Mcleod,Maria Jesus Pareja,Marco Y. W. Zaki,Per Stal,Stergios Kechagias,Anna Ludovica Fracanzani,Luca Valenti,Antonio Grieco,Luca Miele,Piero Fariselli,Mohammed Eslam,Salvatore Petta,Hannes Hagstroem,Jacob George,Joern M. Schattenberg,Manuel Romero-Gomez,Quentin Mark Anstee,Elisabetta Bugianesi
Gutpp.gutjnl-330815, (2024)
Kushala W. M. Abeysekera,Luca Valenti,Zobair Younossi,John F. Dillon,Alina M. Allen,Mazen Noureddin,Mary E. Rinella,Frank Tacke,Sven Francque,Pere Gines,Maja Thiele,Philip N. Newsome,Indra Neil Guha,Mohammed Eslam,Joern M. Schattenberg,Saleh A. Alqahtani,Marco Arrese,Annalisa Berzigotti,Adriaan G. Holleboom,Cyrielle Caussy,Kenneth Cusi,Michael Roden,Hannes Hagstroem,Vincent Wai-Sun Wong,Vincent Mallet,Laurent Castera,Jeffrey V. Lazarus,Emmanuel A. Tsochatzis
LANCET GASTROENTEROLOGY & HEPATOLOGYno. 1 (2024): 83-91
Rubén Gil-Redondo,Ricardo Conde,Chiara Bruzzone, Maria Luisa Seco,Maider Bizkarguenaga,Beatriz González-Valle, Angela de Diego,Ana Laín,Hansjörg Habisch,Christoph Haudum, Nicolas Verheyen,Barbara Obermayer-Pietsch,Sara Margarita,Serena Pelusi, Ignacio Verde,Nádia Oliveira,Adriana Sousa,Amaia Zabala-Letona, Aida Santos-Martin,Ana Loizaga-Iriarte,Miguel Unda-Urzaiz,Jasmin Kazenwadel,Georgy Berezhnoy,Tobias Geisler,Meinrad Gawaz,Claire Cannet,Hartmut Schäfer,Tammo Diercks,Christoph Trautwein,Arkaitz Carracedo,Tobias Madl,Luca Valenti,Manfred Spraul,Shelly C. Lu,Nieves Embade,José M. Mato,Oscar Millet
CARDIOVASCULAR DIABETOLOGYno. 1 (2024)
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作者统计
#Papers: 667
#Citation: 22333
H-Index: 78
G-Index: 136
Sociability: 8
Diversity: 3
Activity: 307
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