基本信息
浏览量:153
职业迁徙
个人简介
During this time (1961-1997), Kohn's major area of investigation concerned the mechanisms of action of DNA-targeted anticancer drugs. He demonstrated that bifunctional alkylating agents produce DNA interstrand crosslinks and that this is their major cytotoxic action. He elucidated a new mechanism of drug action on DNA, based on the anthramycin group of antibiotics.
In 1974, he discovered the DNA filter elution phenomenon in which DNA molecules pass through micropore filters at a rate dependent on DNA strand length. Based on these observations, he developed methodology to measure several types of DNA damage in mammalian cells. This methodology was widely used for more than 20 years in many laboratories to study DNA damage and repair in mammalian cells. By DNA filter elution studies, Kohn and his colleagues in 1979-1982 showed that DNA topoisomerases are targets of action of several clinical anticancer drugs. This led to worldwide interest in topoisomerase-targeted drugs that has continued to the present time.
In the 1990's, Kohn and his colleagues began to apply the emerging knowledge of cell cycle checkpoints to study the responses of cancer cells to DNA damage. As an aid to this end, Kohn developed a notation for molecular interaction maps that has recently received considerable interest. In 2015, he continues to collaborate and consult on various DTP projects and with other laboratories.
研究兴趣
论文共 219 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Stéphanie Solier,Jennifer Barb, Barry R. Zeeberg,Sudhir Varma, Mike C. Ryan,Kurt W. Kohn,John N. Weinstein, Peter J. Munson,Yves Pommier
crossref(2023)
Joseph Riss,Chand Khanna, Seongjoon Koo,Gadisetti V.R. Chandramouli,Howard H. Yang,Ying Hu, David E. Kleiner,Andreas Rosenwald,Carl F. Schaefer, Shmuel A. Ben-Sasson,Liming Yang, John Powell,
crossref(2023)
crossref(2023)
Joseph Riss,Chand Khanna, Seongjoon Koo,Gadisetti V.R. Chandramouli,Howard H. Yang,Ying Hu, David E. Kleiner,Andreas Rosenwald,Carl F. Schaefer, Shmuel A. Ben-Sasson,Liming Yang, John Powell,
crossref(2023)
Joseph Riss,Chand Khanna, Seongjoon Koo,Gadisetti V.R. Chandramouli,Howard H. Yang,Ying Hu, David E. Kleiner,Andreas Rosenwald,Carl F. Schaefer, Shmuel A. Ben-Sasson,Liming Yang, John Powell,
crossref(2023)
Joseph Riss,Chand Khanna, Seongjoon Koo,Gadisetti V.R. Chandramouli,Howard H. Yang,Ying Hu, David E. Kleiner,Andreas Rosenwald,Carl F. Schaefer, Shmuel A. Ben-Sasson,Liming Yang, John Powell,
crossref(2023)
Joseph Riss, Chand Khanna, Seongjoon Koo,Gadisetti V.R. Chandramouli,Howard H. Yang,Ying Hu, David E. Kleiner,Andreas Rosenwald, Carl F. Schaefer, Shmuel A. Ben-Sasson,Liming Yang, John Powell,
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn