Dermatologists all over the world were saddened by the sudden death of Kunihiko Tamaki, professor emeritus of the Department of Dermatology at the University of Tokyo, on 24 July 2010, in Tokyo, Japan. Kuni was an excellent physician and a scientist of tremendous breadth whose work clarified immunological properties of skin, especially those of Langerhans cells (LCs). His leadership in clinical and investigative dermatology in Japan and Asia, his friendship with dermatologists all over the world, and, most of all, his love of science made him a beloved mentor, colleague, and scholar. Kuni was born on Sado Island, Niigata prefecture, on 11 March 1946. He graduated from the University of Tokyo Faculty of Medicine in 1973, and during his residency (under Atsushi Kukita), his excellent clinical eye led to the publication of the first Japanese case of Muckle–Wells syndrome, now known as the cryopyrin-associated periodic syndrome. In 1978, Kuni went to the National Institutes of Health (NIH) to work under Stephen Katz as the first fellow from Kukita’s department at the University of Tokyo. Kuni’s great success at the NIH stimulated young dermatologists not only at the University of Tokyo but also from all over Japan. I was certainly one of them. Kuni studied the origin and function of LCs, discovering, as he published in Nature, that LCs expressed Ia antigens and were derived from bone marrow. Kuni published several papers in JID on LC function in allergic contact dermatitis and allo-delayed type hypersensitivity reactions. After returning to Japan in 1980, he continued to work on LC function. In 1988, he became professor and chairman of the Department of Dermatology at Yamanashi Medical University, where I am now director of the University Hospital. At Yamanashi, even as a chair, Kuni was doing his own experiments, which was not at all common among Japanese clinical professors. Kuni clearly enjoyed performing research, with his fellows, in a small laboratory. In 1994, Kuni was recruited to become professor and chairman of the Department of Dermatology at the University of Tokyo, where he worked until 2009. At least in the early years in Tokyo, Kuni again enjoyed doing research with his young graduate students, and he invented the panning technique to purify murine LCs. This work clarified the functional differences between LCs and other dendritic cells (DCs), one of the major topics in DC biology. The work was well received, and he was subsequently recruited to organize the 8th International Langerhans Cell Workshop in Tokyo in 2003, the first of these workshops to be held in Asia. Kuni’s research interests extended to many other dermatological disorders, including atopic dermatitis (AD), scleroderma and other collagen diseases, and autoimmune bullous diseases. His chemokine studies in AD led to the insurance listing of serum TARC (CCR4 ligand) values as an indicator of disease activity. In 2008, Kuni received the David Martin Carter Award from the Society for Investigative Dermatology at the International Investigative Dermatology (IID) meeting in Kyoto. As president of the IID 2008, I was very happy to see Kuni receive this prestigious award in the Kyoto Conference Center from Barbara Gilchrest of Boston University. From 2002 to 2008, Kuni served as the President of the Japanese Dermatological Association (JDA), and he made significant contributions to its development. In particular, he worked tirelessly on reforms that focused on the future of the JDA, such as promoting its educational role at meetings—a role that is similar to that of the American Academy of Dermatology. In 2006, he became chairman of the Asian Dermatological Association. After retiring, Kuni opened a private practice—a surprising move, because professors of clinical departments at the University of Tokyo usually became directors of large hospitals in the Tokyo area. This decision demonstrated Kuni’s modesty and love of science and clinical dermatology. Immediately after the party celebrating the first anniversary of his private practice, he suffered acute heart failure and passed away in the taxi while returning home.