Kiyoshi Takasuna - New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd

基本信息

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职业迁徙

个人简介

Non-clinical safety Safety assessment using hiPS-cardiomyocytes or nerves Genotoxicity Safety pharmacology

研究兴趣

论文共 48 篇作者统计合作学者相似作者

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Bayesian Approach Enabled Objective Comparison of Multiple Human Ipsc-Derived Cardiomyocytes’ Proarrhythmia Sensitivities

Tetsuro Wakatsuki,Neil Daily,Sunao Hisada,Kazuto Nunomura,Bangzhong Lin, Ko Zushida,Yayoi Honda, Mahoko Asyama,Kiyoshi Takasuna

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2024)

引用0浏览0WOS引用

N-Aryl Indoles As a Novel Class of Potent NaV1.7 Inhibitors

Narayan Karanjule,Noriyuki Hayashi,Sayaka Suzuki,Toshifumi Tsuda,Eri Tokumaru,Kyosuke Tanaka,Hiroko Kimoto,Yuki Domon,Sakiko Takahashi,Kazufumi Kubota,Yutaka Kitano,Tomihisa Yokoyama,Ryuta Koishi,Chie Fujiwara,Shinichi Inaba,Daigo Asano,Tomoko Sakakura,Kiyoshi Takasuna,Tsuyoshi Shinozuka

ACS MEDICINAL CHEMISTRY LETTERSno. 6 (2023): 788-793

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Reliable identification of cardiac liability in drug discovery using automated patch clamp III: Best practices for Ca_V1.2 current in a high throughput screening environment

Alison Obergrussberger,Nina Brinkwirth,Nadine Becker,Kiyoshi Takasuna, Matthias Voemel, Sarah Rimpel, Susanne Herbold, Nina Glaser, Thomas Schnellbaecher,Hatsue Furukawa,Yuka Hasegawa,Takayuki Oka,Tim Strassmaier,Aaron Randolph,Niels Fertig,Sonja Stoelzle-Feix

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2023)

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Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Experimental and Technical Considerations for High Throughput Recordings of NaV1.5 and Herg

Maria Giustina Rotordam,Alison Obergrussberger,Nina Brinkwirth,Kiyoshi Takasuna,Nadine Becker,Andras Horvath,Hatsue Furukawa,Yuka Hasegawa,Takayuki Oka,Niels Fertig,Sonja Stoelzle-Feix

Biophysical Journal（2022）

引用0浏览0引用

Reliable Identification of Heart Disease in Drug Discovery Using Automated Patch Clamps: Benchmarking Best Practices and Calibration Criteria for Improved Proarrhythmic Assessment

Masafumi Doi,Nina Brinkwirth,Kiyoshi Takasuna,Nadine Becker,Alison Obergrussberger,Soren Friis,Hatsue Furukawa,Yuka Hasegawa,Takayuki Oka,Atsushi Ohtsuki,Niels Fertig,Sonja Stoelzle-Feix

Journal of Pharmacological and Toxicological Methods（2021）

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Reliable Identification of Cardiac Conduction Abnormalities in Drug Discovery Using Automated Patch Clamp II: Best Practices for Nav1.5 Peak Current in a High Throughput Screening Environment

Maria Giustina Rotordam,Alison Obergrussberger,Nina Brinkwirth,Kiyoshi Takasuna,Nadine Becker,Andras Horvth,Tom A. Goetze,Markus Rapedius,Hatsue Furukawa,Yuka Hasegawa,Takayuki Oka,Niels Fertig,Sonja Stoelzle-Feix

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS（2021）

引用5浏览0WOS引用

Reliable Identification of Cardiac Liability in Drug Discovery Using Automated Patch Clamp: Benchmarking Best Practices and Calibration Standards for Improved Proarrhythmic Assessment

Nina Brinkwirth,Kiyoshi Takasuna,Masafumi Doi,Nadine Becker,Alison Obergrussberger,Soren Friis,Hatsue Furukawa,Yuka Hasegawa,Takayuki Oka,Atsushi Ohtsuki,Niels Fertig,Sonja Stoelzle-Feix

Journal of pharmacological and toxicological methods（2020）

引用12浏览0WOS引用

Comprehensive Cardiac Safety Assessment Using Hips-Cardiomyocytes (consortium for Safety Assessment Using Human Ips Cells: CSAHi)

Kiyoshi Takasuna,Katsuyuki Kazusa,Tomohiro Hayakawa

Current pharmaceutical biotechnology（2020）

引用2浏览0引用

Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment

Yumiko Asahi,Fumimasa Nomura,Yasuyuki Abe,Masafumi Doi,Tomoko Sakakura,Kiyoshi Takasuna,Kenji Yasuda

European journal of pharmacology（2018）

引用10浏览0WOS引用

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