基本信息
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职业迁徙
个人简介
Areas of interest:
Structure, function, and assembly of the eukaryotic flagella.
Current research:
Cilia are hair-like structures protruding out of the cell, taking part in a wide variety of biological processes. Since the cilia play an essential role in the development and function of the cell, cilia-related diseases usually have detrimental effects on the development and the health of patients such as retardation, blindness and chronic respiratory diseases. Understanding how cilia function, will provide opportunities to effectively diagnose and treat cilia-related diseases. Our research focuses on elucidating the three-dimensional structure of the cilia and the underlying logistic system used to dynamically maintain and assemble the cilia. We aim to obtain high resolutions of various components of the cilia by cryo-electron microscopy and cryo-electron tomography. Together with complementary data, we will model the atomic structures of cilia components to get novel insights into the molecular mechanism of ciliary assembly. In addition, we will also use correlative light and electron microscopy to explore the ciliary dynamics.
Structure, function, and assembly of the eukaryotic flagella.
Current research:
Cilia are hair-like structures protruding out of the cell, taking part in a wide variety of biological processes. Since the cilia play an essential role in the development and function of the cell, cilia-related diseases usually have detrimental effects on the development and the health of patients such as retardation, blindness and chronic respiratory diseases. Understanding how cilia function, will provide opportunities to effectively diagnose and treat cilia-related diseases. Our research focuses on elucidating the three-dimensional structure of the cilia and the underlying logistic system used to dynamically maintain and assemble the cilia. We aim to obtain high resolutions of various components of the cilia by cryo-electron microscopy and cryo-electron tomography. Together with complementary data, we will model the atomic structures of cilia components to get novel insights into the molecular mechanism of ciliary assembly. In addition, we will also use correlative light and electron microscopy to explore the ciliary dynamics.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
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PLANT PHYSIOLOGYno. 1 (2024): 112-123
Structureno. 12 (2023): 1518-1519
Shintaroh Kubo,Corbin S. Black,Ewa Joachimiak,Shun Kai Yang,Thibault Legal,Katya Peri,Ahmad Abdelzaher Zaki Khalifa,Avrin Ghanaeian,Caitlyn L. McCafferty,Melissa Valente-Paterno, Chelsea De Bellis, Phuong M. Huynh,Zhe Fan, Edward M. Marcotte,Dorota Wloga,Khanh Huy Bui
Zenodo (CERN European Organization for Nuclear Research) (2023)
bioRxiv : the preprint server for biology (2023)
STRUCTUREno. 12 (2023): 1518-1519
bioRxiv the preprint server for biology (2023)
Thibault Legal, Mireya Parra, Maxwell Tong,Corbin S. Black,Ewa Joachimiak,Melissa Valente-Paterno,Karl Lechtreck,Jacek Gaertig,Khanh Huy Bui
The journal of cell biology/The Journal of cell biologyno. 11 (2023)
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作者统计
#Papers: 76
#Citation: 4545
H-Index: 29
G-Index: 67
Sociability: 6
Diversity: 0
Activity: 1
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