基本信息
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Bio
RNA polymerase III (Pol III) transcribes genes encoding tRNA, 5S ribosomal RNA, and other classes of small noncoding RNA involved in translation and other critical processes. Pol III activity is a prerequisite for cell growth and is linked to nutrient availability and extracellular growth cues via oncogenic and tumor-suppressor signaling pathways. Aberrant activation of growth signaling factors can lead to elevated levels of Pol III transcription, a hallmark of cancer.
My lab uses genomic approaches to investigate Pol III transcription dynamics during differentiation and in response to extracellular cues and signaling events. We are particularly interested in understanding the regulatory mechanisms that promote or restrict Pol III activity and which underly Pol III dysregulation in cancer. Our recent work suggests that a specific Pol III subunit, POLR3G, which is highly expressed in proliferative cells and a myriad of cancer contexts, enhances Pol III transcription and drives expression of small NF90-associated (SNAR-A) noncoding RNA. We seek to better understand the mechanism of POLR3G-enhanced transcription, the function of SNAR-A and other Pol III-transcribed small RNA, and the role of POLR3G as a potential disease factor and future therapeutic target.
Research Interests
Research Topics
Chromatin Structure, Computational Biology, Genome Organization, Genomics, Regulation of Gene Expression, RNA Biology
Disease Research Interests
Cancer, Drug Discovery
Research Interests
Papers共 37 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv the preprint server for biology (2024)
Deepak K. Singh, Zhengmin Cong,You Jin Song, Minxue Liu,Ritu Chaudhary,Dazhen Liu,Yu Wang, Rishabh Prasanth, K. C. Rajendra,Simon Lizarazo, Miriam Akhnoukh,Omid Gholamalamdari, Anurupa Moitra,Lisa M. Jenkins,Rohit Bhargava,Erik R. Nelson,Kevin Van Bortle,Supriya G. Prasanth,Kannanganattu V. Prasanth
MOLECULAR AND CELLULAR BIOLOGYno. 9 (2024): 372-390
Cancersno. 20 (2023): 4995-4995
Morteza Roodgar,Fabian P. Suchy,Lan H. Nguyen,Vivek K. Bajpai,Rahul Sinha,Jose G. Vilches-Moure,Kevin Van Bortle,Joydeep Bhadury,Ahmed Metwally,Lihua Jiang,Ruiqi Jian,Rosaria Chiang,Angelos Oikonomopoulos,Joseph C. Wu,Irving L. Weissman,Joseph L. Mankowski,Susan Holmes,Kyle M. Loh,Hiromitsu Nakauchi,Catherine A. VandeVoort,Michael P. Snyder
Qing Liu,Haodi Wu,Zhana Duren,Chao Jiang,Kevin Van Bortle,Mingtao Zhao,Hongchao Guo,Chenchen Zhu,Qing-Jun Luo,Bingqing Zhao, Jun Liu,David Marciano,Joshua Gruber,Andrew Lipchik,Anil Narasimha,Nathaniel Watson,Ming-Shian Tsai,Takaaki Furihata,Lei Tian,Eric Wei,Yingxin Li,Lars Steinmetz,Wing H. Wong,Mark Kay,Joseph Wu,Michael Snyder
Research Square (Research Square) (2022)
Qing Liu,Haodi Wu,Qing-Jun Luo,Chao Jiang,Zhana Duren,Kevin Van Bortle,Ming-tao Zhao,Bingqing Zhao, Jun Liu,David P Marciano,Brittany Lee-McMullen,Chenchen Zhu,Anil M Narasimha,Joshua J Gruber,Andrew M Lipchik,Hongchao Guo,Nathaniel K Watson,Ming-Shian Tsai,Takaaki Furihata,Lei Tian,Eric Wei,Yingxin Li,Lars M Steinmetz,Wing Hung Wong,Mark A. Kay,Joseph C Wu,Michael P Snyder
bioRxiv (Cold Spring Harbor Laboratory)pp.1-48, (2020)
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Author Statistics
#Papers: 37
#Citation: 1104
H-Index: 17
G-Index: 24
Sociability: 5
Diversity: 2
Activity: 12
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