基本信息
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职业迁徙
个人简介
My laboratory studies cancer and inflammation in the gastrointestinal tract by integrating genetically engineered mouse models with biochemistry and structural biology, proteomics and genomics, and bioinformatics and systems biology. Our primary cancer research goal over the past decade has been to understand the biology of the RAS family oncogenes at a level that will allow us to design and implement precision medicine approaches for RAS-mutant colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). Our work has helped to refine the fundamental principles of precision medicine, in particular by demonstrating that closely related cancer genes, and allelic forms of the same gene, can be functionally distinct and therefore require distinct therapeutic interventions. Through our work, my laboratory has strongly integrated into the HMS and Broad Institute cancer research community. Our ongoing work focuses on the application of mass spectrometry to mouse models of K-RAS driven cancer, the identification of synthetic lethal partners with mutant forms of K-RAS, understanding allele-specific functions of K-RAS across gastrointestinal cancers, and the development of computational models of K-RAS signaling and genetics.
研究兴趣
论文共 154 篇作者统计合作学者相似作者
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Riaz Gillani,Ryan L Collins,Jett Crowdis, Amanda Garza,Jill K Jones,Mark Walker,Alba Sanchis-Juan, Chris Whelan,Emma Pierce-Hoffman,Michael Talkowski,Harrison Brand,Kevin Haigis,Jaclyn LoPiccolo,Saud H AlDubayan,Alexander Gusev,Brian D Crompton, Katie A Janeway,Eliezer M Van Allen
bioRxiv : the preprint server for biology (2024)
openalex(2024)
Christian William Johnson,Elizabeth M. Terrell, Josh Cook,Bing Shui, Eve O'Donoghue, Shannon Hull,Moon Hee Yang, Shikha Sheth, Rona Yaeger,Scott Kopetz,Deborah K. Morrison,Kevin Haigis
Cancer Researchno. 6_Supplement (2024): 6623-6623
crossref(2024)
Jing Xu,Kevin M. Haigis,Ari Firestone,Megan E. McNerney,Qing Li, Elizabeth Davis,Shann-Ching Chen,Joy Nakitandwe, James R. Downing,Tyler Jacks, Michelle M. Le Beau,Kevin Shannon
openalex(2023)
Moon Hee Yang,Timothy H. Tran, Bethany Hunt, Rebecca Agnor,Christian W. Johnson,Bing Shui,Timothy J. Waybright,Jonathan A. Nowak,Andrew G. Stephen,Dhirendra K. Simanshu,Kevin M. Haigis
openalex(2023)
crossref(2023)
crossref(2023)
Jing Xu,Kevin M. Haigis,Ari Firestone,Megan E. McNerney,Qing Li, Elizabeth Davis,Shann-Ching Chen,Joy Nakitandwe, James R. Downing,Tyler Jacks, Michelle M. Le Beau,Kevin Shannon
openalex(2023)
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作者统计
#Papers: 155
#Citation: 7772
H-Index: 44
G-Index: 88
Sociability: 7
Diversity: 3
Activity: 162
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