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个人简介
He has a longstanding interest in human cancer-prone genetic diseases and DNA repair. His studies focus on molecular, cellular, and clinical features of diseases including xeroderma pigmentosum and trichothiodystrophy. He is a member of the American Society for Clinical Investigation and has received awards from the Society for Investigative Dermatology and the U.S. Public Health Service.
We are investigating the role of DNA repair in prevention of cancer and in human development. We perform clinical, molecular, and translational investigations of two rare genetic disorders with defective DNA repair: xeroderma pigmentosum (XP) with clinical and cellular hypersensitivity to ultraviolet radiation and a 10,000-fold increased risk of skin cancer and trichothiodystrophy, a disorder with developmental abnormalities and defects in some of the same genes as XP without increased cancer risk. We recently found that the molecular changes in skin melanomas from the XP patients were closely related to sun exposure and different from the general population.
Areas of Expertise
1) DNA repair 2) UV damage 3) skin cancer 4) primary melanoma 5) xeroderma pigmentosum 6) trichothiodystrophy
研究兴趣
论文共 284 篇作者统计合作学者相似作者
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Elvelyn R. Fernandez,Deborah Tamura,Sikandar G. Khan,Sophie Momen,Hiva Fassihi,Robert Sarkany,John J. Digiovanna,Kenneth H. Kraemer
Frontiers in Oncology (2023): 1282823
John J. DiGiovanna,Grant Randall, Alexandra Edelman, Rina Allawh, Michael Xiong,Deborah Tamura,Sikandar G. Khan, Elizabeth R. H. Rizza,James C. Reynolds,Scott M. Paul,Suvimol C. Hill,Kenneth H. Kraemer
American Journal of Medical Genetics Part Ano. 12 (2022): 3448-3462
American journal of medical genetics. Part Ano. 12 (2022): 3448-3462
Angeliki-Diotima Ioannidis,Sikandar G Khan,Deborah Tamura,John J DiGiovanna, Elizabeth Rizza,Kenneth H Kraemer,Robert H Rice
T. Lehky, P. Sackstein, D. Tamura, M. Quezado,T. Wu, S.G. Khan,N.J. Patronas, E. Wiggs,C.C. Brewer, J.J. DiGiovanna,K.H. Kraemer
J. Jeskey, E.H. Rizza, M. Sarihan, S.G. Khan,J. Boyle, D. Tamura,N. Mendelsohn,B.P. Brooks, M. Merideth, J.J. DiGiovanna,K.H. Kraemer
A. Ho, E. H. Rizza, J. Jeskey, S. Folarin, D. Tamura,S. G. Khan,X. Zhou, J. J. Digiovanna, C. L. Evans,K. H. Kraemer
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