AWARDS AND HONORS NSF CAREER Award, 2007 Presidential Early Career Award for Scientists and Engineers (PECASE), 2008 Achievement Award for Outstanding Mentor of Graduate/Professional Students (GPS), GPS Council, 2010 Fellow of the American Association for the Advancement of Science (AAAS), 2013 College of Science Distinguished Advising Award, University of Arizona, 2014 Cell survival, development, replication, repair and adaptation depend on the ability to sense and respond to acute and chronic environmental changes. One mechanism by which cells detect, communicate and adjust to changing conditions involves chemical modifications to proteins, DNA and lipids. A subset of these modifications is mediated by small, redox active molecules, including reactive oxygen species (ROS), which are produced by reduction of molecular oxygen, and reactive nitrogen species (RNS), which typically originate from and are more oxidized than nitric oxide (NO). Redox signaling is a major component of intracellular communication, immune response and wound healing but can also contribute to chemical stress and cell death when dysregulated.