Kathryn A Giblin - Medicinal Chemistry, Research and Early Development, AstraZeneca

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论文共 17 篇作者统计合作学者相似作者

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Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design

Taylor R. Quinn,Kathryn A. Giblin, Clare Thomson,Jeffrey A. Boerth,Gayathri Bommakanti,Erin Braybrooke, Christina Chan,Alex J. Chinn,Erin Code, Caifeng Cui,Yukai Fan,Neil P. Grimster,Keishi Kohara,Michelle L. Lamb, Lina Ma,Adelphe M. Mfuh,Graeme R. Robb,Kevin J. Robbins,Marianne Schimpl, Haoran Tang, Jamie Ware,Gail L. Wrigley,Lin Xue, Yun Zhang, Huimin Zhu,Samantha J. Hughes

JOURNAL OF MEDICINAL CHEMISTRYno. 16 (2024): 14210-14233

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Discovery, Optimization, and Biological Evaluation of Arylpyridones As Cbl-b Inhibitors

Adelphe M. Mfuh,Jeffrey A. Boerth,Gayathri Bommakanti, Christina Chan,Alex J. Chinn,Erin Code, Patrick J. Fricke,Kathryn A. Giblin,Andrea Gohlke, Catherine Hansel,Niresh Hariparsad,Samantha J. Hughes,Meizhong Jin,Vasudev Kantae,Stefan L. Kavanagh,Michelle L. Lamb,Jordan Lane,Rachel Moore,Taranee Puri, Taylor R. Quinn, Iswarya Reddy,Graeme R. Robb,Kevin J. Robbins, Miguel Gancedo Rodrigo,Marianne Schimpl, Baljinder Singh,Meha Singh, Haoran Tang, Clare Thomson,Jarrod J. Walsh, Jamie Ware,Iain D. G. Watson,Min-Wei Ye,Gail L. Wrigley,Andrew X. Zhang, Yun Zhang,Neil P. Grimster

JOURNAL OF MEDICINAL CHEMISTRYno. 2 (2024): 1500-1512

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First disclosure of a highly potent and selective HPK1 inhibitor that rescues T cell exhaustion

Deanna A. Mele,Neil Grimster,Gayathri Bommakanti, Jason Shields, Lucas Morrill,Kathryn Giblin, Maryann SanMartin,Yanjun Wang,Minwei Ye, Iswarya KarapaReddy,Kun Song,Theresa Proia,Niresh Hariparsad, Ryan Richards,Nadia Luheshi, Simon T. Barry,Stephen Fawell

CANCER RESEARCHno. 7 (2023)

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Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity

Jeffrey A. Boerth,Alex J. Chinn,Marianne Schimpl,Gayathri Bommakanti, Christina Chan,Erin L. Code,Kathryn A. Giblin,Andrea Gohlke, Catherine S. Hansel,Meizhong Jin,Stefan L. Kavanagh,Michelle L. Lamb, Jordan S. Lane,Carrie J. B. Larner,Adelphe M. Mfuh,Rachel K. Moore,Taranee Puri, Taylor R. Quinn,Minwei Ye,Kevin J. Robbins, Miguel Gancedo-Rodrigo, Haoran Tang,Jarrod Walsh, Jamie Ware,Gail L. Wrigley, Iswarya Karapa Reddy, Yun Zhang,Neil P. Grimster

ACS medicinal chemistry lettersno. 12 (2023): 1848-1856

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Abstract 3453: First Disclosure of a Highly Potent and Selective HPK1 Inhibitor That Rescues T Cell Exhaustion

Deanna A. Mele,Neil Grimster,Gayathri Bommakanti, Jason Shields,Lucas Morrill,Kathryn Giblin, Maryann SanMartin,Yanjun Wang,Minwei Ye, Iswarya KarapaReddy,Kun Song,Theresa Proia,Niresh Hariparsad, Ryan Richards,Nadia Luheshi, Simon T. Barry,Stephen Fawell

Cancer Researchno. 7_Supplement (2023): 3453-3453

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De Novo Design with Deep Generative Models Based on 3D Similarity Scoring

Kostas Papadopoulos,Kathryn A. Giblin,Jon Paul Janet,Atanas Patronov,Ola Engkvist

Bioorganic & medicinal chemistry（2021）

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De novo design with deep generative models based on 3D similarity scoring (vol 44, 116308, 2021)

Kostas Papadopoulos,Kathryn A. Giblin,Jon Paul Janet,Atanas Patronov,Ola Engkvist

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

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Erratum to “de Novo Design with Deep Generative Models Based on 3D Similarity Scoring” [bioorg. Med. Chem. 44 (2021) 116308]

Kostas Papadopoulos,Kathryn A. Giblin,Jon Paul Janet,Atanas Patronov,Ola Engkvist

Bioorganic & medicinal chemistry（2021）

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Uncertainty quantification in drug design

Lewis H. Mervin,Simon Johansson, Elizaveta Semenova,Kathryn A. Giblin,Ola Engkvist

Drug Discovery Todayno. 2 (2021): 474-489

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Additional File 1 of DockStream: a Docking Wrapper to Enhance De Novo Molecular Design

Jeff Guo,Jon Paul Janet,Matthias R. Bauer, Eva Nittinger,Kathryn A. Giblin,Kostas Papadopoulos,Alexey Voronov,Atanas Patronov,Ola Engkvist,Christian Margreitter

Figshare (2021)

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