Karina R Bortoluci

基本信息

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职业迁徙

个人简介

The main focus of my lab is understanding the molecular basis of innate immune recognition by using the experimental models of Salmonella typhimurium and Trypanosoma cruzi infections.

研究兴趣

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Caspase-1/11 Controls Zika Virus Replication in Astrocytes by Regulating Glycolytic Metabolism

Ingrid S. Farias, Guilherme Ribeiro,Isaú H. Noronha,Jean P. S. Peron, Pedro M. Moraes Vieira,Jose C. Alves-Filho,Karina R. Bortoluci

crossref（2024）

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Three Main SCFAs Mitigate Lung Inflammation and Tissue Remodeling Nlrp3-Dependent in Murine HDM-Induced Neutrophilic Asthma

Barbara S. S. Tagé,Michelangelo B. Gonzatti,Rodolfo P. Vieira,Alexandre C. Keller,Karina R. Bortoluci,Flávio Aimbire

INFLAMMATIONno. 4 (2024): 1386-1402

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Molecular Regulation of NAIP/NLRC4 Inflammasomes

Marcelo Pires Amaral,Laura Migliari Branco,Silvia Lucena Lage,Karina Ramalho Bortoluci

Inflammasome Biologypp.77-91, (2023)

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NAIP/NLRC4 Inflammasome Participates in Macrophage Responses to Trypanosoma Cruzi by a Mechanism That Relies on Cathepsin-Dependent Caspase-1 Cleavage

Marcelo Pires Amaral, Felipe Daniel Cardoso, Ingrid Sancho de Farias, Rafael Queiroz de Souza,Kely Catarine Matteucci,Ana Claudia Torrecilhas,Karina Ramalho Bortoluci

FRONTIERS IN IMMUNOLOGY (2023)

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Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer

Mariana Teixeira Rodrigues, Ana Paula Picaro Michelli, Gustavo Felisola Caso, Paloma Ramos de Oliveira,Dorival Mendes Rodrigues-Junior,Mirian Galliote Morale,Joel Machado Junior,Karina Ramalho Bortoluci,Rodrigo Esaki Tamura,Tamiris Reissa Cipriano da Silva,Cristiano Raminelli,Eric Chau,Biana Godin,Jamile Calil-Silveira,Ileana G. Sanchez Rubio

PHARMACEUTICALS（2023）

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Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion

Laura Migliari Branco,Marcelo Pires Amaral,Henning Boekhoff,Ana Beatriz Figueiredo de Lima,Ingrid Sancho Farias,Silvia Lucena Lage,Gustavo José Silva Pereira,Bernardo Simões Franklin,Karina Ramalho Bortoluci

Cell Death Dis（2022）

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Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity Against Trypanosoma Cruzi in Vitro and in Vivo

Ramendra P. Pandey,Marilda Savoia Nascimento,Caio Haddad Franco,Karina Bortoluci,Marcelo Nunes Silva,Bianca Zingales,Daniel Gibaldi,Leda Castano Barrios,Joseli Lannes-Vieira,Leonardo Moro Cariste,Jose Ronnie Vasconcelos,Carolina Borsoi Moraes,Lucio H. Freitas-Junior,Jorge Kalil,Laura Alcantara,Edecio Cunha-Neto

Antimicrobial Agents and Chemotherapy（2022）

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Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1 secretion

Laura Migliari Branco,Marcelo Pires Amaral,Henning Boekhoff,Ana Beatriz Figueiredo de Lima,Ingrid Sancho Farias,Silvia Lucena Lage,Gustavo Jose Silva Pereira,Bernardo Simoes Franklin,Karina Ramalho Bortoluci

CELL DEATH & DISEASE（2022）

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Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization with ASP2 of Trypanosoma Cruzi

Barbara Ferri Moraschi,Isau Henrique Noronha,Camila Pontes Ferreira, Leonardo M. Cariste, Caroline B. Monteiro,Priscila Denapoli,Talita Vrechi,Gustavo J. S. Pereira,Ricardo T. Gazzinelli,Joseli Lannes-Vieira,Mauricio M. Rodrigues,Karina R. Bortoluci,Jose Ronnie C. Vasconcelos

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY（2021）

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CXCR3 Chemokine Receptor Contributes to Specific CD8+ T Cell Activation by Pdc During Infection with Intracellular Pathogens (vol 14, E0008414, 2020)

Camila Pontes Ferreira,Leonardo Moro Cariste,Isau Henrique Noronha,Danielle Fernandes Durso,Joseli Lannes-Vieira,Karina Ramalho Bortoluci,Daniel Araki Ribeiro,Douglas Golenbock,Ricardo Tostes Gazzinelli,Jose Ronnie Carvalho de Vasconcelos

PLOS NEGLECTED TROPICAL DISEASES（2021）

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