Joseph F. Arboleda-Velasquez
副教授
Age-related Macular Degeneration Center of Excellence
Department of Ophthalmology, Harvard Medical School, Harvard University;Diabetic Eye Disease Center of Excellence, Department of Ophthalmology, Harvard Medical School, Harvard University;Schepens Eye Research Institute, Harvard University;Massachusetts Eye and Ear, Harvard University
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个人简介
Dr. Arboleda-Velasquez’s research is focused on the genetics and pathobiology of neurodegenerative diseases of the brain and the retina.
Dr. Arboleda-Velasquez’s early career work on CADASIL, an inherited form of stroke and vascular dementia, took him from the clinical characterization of two families in his home country of Colombia to Harvard Medical School, where he conducted molecular studies of mutant Notch 3 receptors in culture systems. He also generated novel knock-in mouse models that replicated a genotype-phenotype correlation first observed in his CADASIL patients, and leveraged inducible cell ablation studies in mice to provide evidence that pericytes help regulate microvascular stability in adult neural tissues. Dr. Arboleda-Velasquez recently took his CADASIL work towards translational applications by characterizing blood biomarkers linked to the pathobiology of the disease and by establishing the preclinical feasibility of a treatment modality based on Notch 3 signaling normalization using therapeutic antibodies.
Dr. Arboleda-Velasquez’s early career work on CADASIL, an inherited form of stroke and vascular dementia, took him from the clinical characterization of two families in his home country of Colombia to Harvard Medical School, where he conducted molecular studies of mutant Notch 3 receptors in culture systems. He also generated novel knock-in mouse models that replicated a genotype-phenotype correlation first observed in his CADASIL patients, and leveraged inducible cell ablation studies in mice to provide evidence that pericytes help regulate microvascular stability in adult neural tissues. Dr. Arboleda-Velasquez recently took his CADASIL work towards translational applications by characterizing blood biomarkers linked to the pathobiology of the disease and by establishing the preclinical feasibility of a treatment modality based on Notch 3 signaling normalization using therapeutic antibodies.
研究兴趣
论文共 105 篇作者统计合作学者相似作者
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Paula Perez-Corredor, Timothy E Vanderleest,Guido N Vacano,Justin S Sanchez, Nelson D Villalba-Moreno,Claudia Marino,Susanne Krasemann,Miguel A Mendivil-Perez,David Aguillón,Marlene Jiménez-Del-Río,Ana Baena,Diego Sepulveda-Falla,
Frontiers in molecular neuroscience (2024): 1373568-1373568
Claudia Marino, Paula Perez-Corredor,Michael O'Hare, Annie Heuer,Natalia Chmielewska, Harper Gordon, Anita S. Chandrahas,Lucia Gonzalez-Buendia,Santiago Delgado-Tirado, Tri H. Doan, Timothy E. Vanderleest,Said Arevalo-Alquichire,
ALZHEIMERS & DEMENTIAno. 2 (2024): 819-836
Jonah N. Keller,Hannah Radabaugh,Nikolaos Karvelas,Stephen Fitzsimons, Scott Treiman, Maria F. Palafox, Lisa McDonnell,Yakeel T. Quiroz,Francisco J. Lopera, Debarag Banerjee,Michael M. Wang,Joseph F. Arboleda-Velasquez,
crossref(2024)
Paula Perez-Corredor, Timothy E. Vanderleest,Guido N. Vacano,Justin S. Sanchez, Nelson D. Villalba-Moreno,Claudia Marino,Susanne Krasemann,Miguel A. Mendivil-Perez,David Aguillon,Marlene Jimenez-Del-Rio,Ana Baena,Diego Sepulveda-Falla,
FRONTIERS IN MOLECULAR NEUROSCIENCE (2024)
Paula Perez-Corredor, Timothy E. Vanderleest,Guido N. Vacano,Justin S. Sanchez, Nelson D. Villalba-Moreno,Claudia Marino,Susanne Krasemann,Miguel A. Mendivil-Perez,David Aguillón,Marlene Jiménez-Del-Río,Ana Baena,Diego Sepulveda-Falla,
Frontiers in Molecular Neuroscience (2024)
Francisco Lopera,Claudia Marino, Anita S. Chandrahas,Michael O’Hare,Nelson David Villalba-Moreno,David Aguillon,Ana Baena,Justin S. Sanchez,Clara Vila-Castelar,Liliana Ramirez Gomez,Natalia Chmielewska, Gabriel M. Oliveira,
Nature Medicineno. 5 (2023): 1243-1252
Nicholas Barksdale,Stephanie Langella,Daniel Vasquez,David Aguillon,Yinghua Chen,Yi Su, Natalia Acosta Baena, Juliana Acosta Uribe,Ana Baena,Gloria Garcia-Ospina,Margarita Giraldo-Chica,Victoria Tirado,
NEUROLOGYno. 17 (2023)
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Nature Communicationsno. 1 (2023): 1-8
Maxine R. Nelson, Peng Liu,Ayushi Agrawal, Oscar Yip,Jessica Blumenfeld,Michela Traglia, Min Joo Kim,Nicole Koutsodendris,Antara Rao,Brian Grone,Yanxia Hao,Seo Yeon Yoon,
Nature Neuroscienceno. 12 (2023): 2104-2121
Julián Henao-Restrepo, Carolina López-Murillo,Pablo Valderrama-Carmona, Natalia Orozco-Santa,Johana Gomez,Johanna Gutiérrez-Vargas, Renato Moraga,Jorge Toledo,Jessica Lisa Littau,Steffen Härtel,Joseph F Arboleda-Velásquez,Diego Sepulveda-Falla,
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