He is heading the Constitutional Cytogenetics unit of the Center of Human Genetics, and coordinating the genomic core. Before taking up his current position, he was head of the genomics unit in the basic research division of Aventis CropScience and responsible for large scale genome analyses in several crops. The laboratory has been pioneering genomic applications with a focus on preimplantation, prenatal and postnatal diagnosis. The group has a special focus on structural variation detection. The laboratory studies the mechanisms underlying chromosomal instability and rearrangements. It actively developed methods for single cell CNV detection and will continue to address outstanding questions about instability using single cell genomic approaches. In collaboration with clinical geneticists, the laboratory actively seeks to define the molecular causes of developmental, mental and behavioural disturbances. The group is partner of the SymbioSys, the systems biology center of excellence in computational biology to mine high throughput data analysis tools and to identify novel gene functions through data fusion methods and, at an institutional level, involved in creating the framework for genomic data storage, analysis and exchange. He has published over 250 papers with an H-index 45.