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个人简介
I have worked in the preclinical pain field since 1985. There is little reason to do such work unless it leads to new pain therapies. Fortunately we have identified a number of new analgesic targets in studies of transgenic mice. An ATP-gated channel that I identified in Geoff Burnstock's department has resulted in a new treatment for chronic cough in the clinic. The drug is called Gefapixant in honour of Geoff! We also cloned a sodium channel named Nav1.8 that is very important for human pain, and Vertex have produced a channel blocker that has succeded in phase 3 trials. Most recently we showed that Nav1.7, another sodium channel, plays a key role in pain, and explained the mechanism behind this. Our recent work focusses on chemogenetic studies of bone cancer pain, where we have had preclinical success.
研究兴趣
论文共 537 篇作者统计合作学者相似作者
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biorxiv(2024)
Ali Bangash,Cankut Cubuk,Federico Iseppon, Rayan Haroun,Ana P Luiz,Manuel Arcangeletti, Samuel J Gossage,Sonia Santana-Varela,James J Cox,Myles J Lewis,John N Wood,Jing Zhao
biorxiv(2024)
Rayan Haroun, Samuel J. Gossage,Federico Iseppon, Alexander Fudge,Sara Caxaria,Manuel Arcangeletti,Charlotte Leese,Bazbek Davletov,James J. Cox,Shafaq Sikandar,Fraser Welsh,Iain P. Chessell,
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2024)
eNeurono. 2 (2023): ENEURO.0395-22.2022
Sungmin Pak,Hyunil Ryu, Thien-Luan Nguyen, Seung Woon Lim, Su min Kang,Yeon Gyu Yu,JunHyuk Woo, Chanjin Kim,Cristina Fenollar–Ferrer,John N. Wood,Mi‐Ock Lee,Gyu-Sang Hong,
Research Square (Research Square) (2023)
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Jing Wang,Qiao-min Ru,Xiao-hui Yu, Changlong Wang,Kai Li,Chao-zhen-yi Han,Na Li, Jing Zhao,John N. Wood,Xin Liu,Rui Wang,Yuan Wang
EUROPEAN JOURNAL OF PHARMACOLOGY (2023): 176182-176182
Rayan Haroun, Samuel J. Gossage,Ana Paula Luiz,Manuel Arcangeletti,Shafaq Sikandar,Jing Zhao,James J. Cox,John N. Wood
ENEUROno. 9 (2023): ENEURO.0151-23.2023
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