Fields of Research Drug discovery and precision medicine Intracellular signaling Molecular basis of disease Research Summary Charting the intracellular signaling landscape is the main goal of our studies. Research Statement A-kinase Anchoring proteins (AKAPs) constrain protein kinases and phosphatases at defined locations within the cell. AKAP signaling is fundamental to the spatial regulation of physiological processes. Our combination of molecular, genetic and structural approaches have shown that local signaling via AKAPs is key to homeostatic mechanisms that go awry in disease states including cardiovascular diseases, diabetes and cancers.