基本信息
浏览量:39
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Jennifer A. Philips is the Co-Director of the Infectious Diseases Division. Dr. Philips is principal investigator of an NIH-funded lab that studies how Mycobacterium tuberculosis evades the host immune response. M. tuberculosis causes TB, one of the world’s most deadly infections. It has infected humans for millenia and is highly adapted to navigate the complexities of the human immune system. The discoveries in the Philips laboratory have delineated how Mtb blocks lysosomal trafficking, alters host metabolism, and impairs antigen presentation. Her laboratory has identified clinically available drugs that restore the ability of the host to clear M. tuberculosis, overcoming key immune evasion strategies of Mtb. These findings may lead to novel host-directed therapies for TB. In recent unpublished work, they showed that the abundance of an M.tuberculosis-host co-metabolite in sputum and plasma distinguishes Mtb-infected patients from uninfected controls. This may enable development of biomarkers to individualize TB treatment. Thus, by making fundamental discoveries in Mtb pathogenesis, her group hopes to enable better therapies, novel biomarkers, and effective vaccines for one of humankind’s greatest afflictions.
研究兴趣
论文共 20 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Steven J. Grigsby, G. V. R. Krishna Prasad,Joshua B. Wallach,Ekansh Mittal,Fong-Fu Hsu,Dirk Schnappinger,Jennifer A. Philips
CELL REPORTSno. 1 (2024): 113607-113607
Cell Reports Methodsno. 8 (2022): 100267
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn