Jean-François Cloutier’s research is aimed at understanding the molecular mechanisms that control axonal pathfinding during development of the nervous systems. The formation of accurate connections between the peripheral and central nervous systems is essential for the functioning of the various sensory systems that allow us to detect odors, sounds, tastes, pain, and temperature. While the basic anatomical principles of wiring in these systems are well understood, little is known about the mechanisms involved in establishing these wiring patterns.

Dr. Cloutier uses a combination of in vivo mouse genetic models and molecular biological approaches to identify cues involved in guiding axons of primary sensory neurons to their targets and to characterize intracellular signals that function downstream of these axon guidance cues. Gaining insight into the basic mode of action of guidance molecules will be important in the future development of therapies for neurological disorders and injuries requiring regeneration of specific axonal connections.