Jacob L. Bouchard - Department of Medicinal Chemistry, University of Minnesota

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Discovery of Protease-Activated Receptor 4 (Par4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening

Shannon T. Smith, Jackson B. Cassada,Lukas Von Bredow,Kevin Erreger, Emma M. Webb, Trevor A. Trombley,Jacob J. Kalbfleisch,Brian J. Bender, Irene Zagol-Ikapitte,Valerie M. Kramlinger,Jacob L. Bouchard, Sidnee G. Mitchell,Maik Tretbar,Brian K. Shoichet,Craig W. Lindsley,Jens Meiler,Heidi E. Hamm

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCEno. 4 (2024): 1086-1100

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Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (C[pro-His-dphe-arg-trp-dap-lys(arg-arg-arg-ac)-dpro]) Decreases Food Intake when Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (C[pro-His-dphe-arg-trp-dap-ala-dpro)]

Mark D. Ericson,Katie T. Freeman,Courtney M. Larson,Jacob L. Bouchard,Kristen John,Mary M. Lunzer,Zoe M. Koerperich,Carrie Haskell-Luevano

ACS Pharmacology & Translational Scienceno. 4 (2024): 1114-1125

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Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-Dphe(pi)-arg-nal(2')-orn-nh2] at the MC1R, MC3R, MC4R, and MC5R That Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-Dphe(pi)-darg-nal(2')-arg-nh2]

Mark D. Ericson,Linh T. Tran,Sarah S. Mathre,Katie T. Freeman, Kelsey Holdaway,Kristen John,Mary M. Lunzer,Jacob L. Bouchard,Carrie Haskell-Luevano

Journal of medicinal chemistry（2023）

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Photocaged dicarbonyl probe provides spatiotemporal control over protein glycation

Alexander K. Hurben,Peng Ge,Jacob L. Bouchard,Todd M. Doran,Natalia Y. Tretyakova

Chemical Communications（2022）

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Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of Α-Synuclein Autoantibodies in Human Plasma

Peng Ge,Mu Yang,Jacob L. Bouchard,Nicolas Dzamko,Simon J. G. Lewis,Glenda M. Halliday,Todd M. Doran

Bioconjugate chemistry（2022）

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Aβ(M1–40) and Wild-Type Aβ40 Self-Assemble into Oligomers with Distinct Quaternary Structures

Jacob L. Bouchard,Taylor C. Davey,Todd M. Doran

Molecules/Molecules online/Molecules annual（2019）

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Preparation of Conformationally Discrete Oligomers for HTS using Privileged Scaffold Libraries

Jacob L. Bouchard, Jacob Patterson,Taylor Davey, Jack Krueger,Todd M. Doran

semanticscholar（2018）

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Branching Ratios, Radiative Lifetimes, and Transition Dipole Moments for Tantalum Nitride, Tan

Jacob L. Bouchard,Timothy Steimle,Damian L. Kokkin,David J. Sharfi,Richard J. Mawhorter

JOURNAL OF MOLECULAR SPECTROSCOPY（2016）

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Spectroscopy of TaN in Support of Fundamental Physics

Richard Mawhorter,David Sharfi,Yongrak Kim,Damian L. Kokkin,Jacob Bouchard,Timothy C. Steimle

Bulletin of the American Physical Society (2016)

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