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Research in the Szostak laboratory is focused on the origin, early evolution and laboratory synthesis of simple living systems.
The complexity of modern biological life has long made it difficult to understand how life could emerge spontaneously from the chemistry of the early earth. The key to resolving this mystery lies in the simplicity of the earliest living cells. Through our efforts to synthesize extremely simple artificial cells, we hope to discover plausible pathways for the transition from chemical evolution to Darwinian evolution. We view the two key components of a primitive cell as a self-replicating nucleic acid genome, and a self-replicating cell membrane. We have recently discovered simple but robust pathways for the coupled growth and division of primitive cell membranes. We are currently engaged in the design and chemical synthesis of modified nucleic acids, including modified versions of RNA, that can replicate without enzymes. By combining self-replicating nucleic acids and membranes we hope to generate model protocells that will allow us to observe the spontaneous emergence of Darwinian behavior.
The complexity of modern biological life has long made it difficult to understand how life could emerge spontaneously from the chemistry of the early earth. The key to resolving this mystery lies in the simplicity of the earliest living cells. Through our efforts to synthesize extremely simple artificial cells, we hope to discover plausible pathways for the transition from chemical evolution to Darwinian evolution. We view the two key components of a primitive cell as a self-replicating nucleic acid genome, and a self-replicating cell membrane. We have recently discovered simple but robust pathways for the coupled growth and division of primitive cell membranes. We are currently engaged in the design and chemical synthesis of modified nucleic acids, including modified versions of RNA, that can replicate without enzymes. By combining self-replicating nucleic acids and membranes we hope to generate model protocells that will allow us to observe the spontaneous emergence of Darwinian behavior.
Research Interests
Papers共 511 篇Author StatisticsCo-AuthorSimilar Experts
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Aman Agrawal,Aleksandar Radakovic, Anusha Vonteddu, Syed Rizvi, Vivian N. Huynh,Jack F. Douglas,Matthew V. Tirrell,Alamgir Karim,Jack W. Szostak
SCIENCE ADVANCESno. 34 (2024)
Aleksandar Radakovic,Anna Lewicka,Marco Todisco,Harry R M Aitken,Zoe Weiss, Shannon Kim, Abdullah Bannan,Joseph A Piccirilli,Jack W Szostak
Proceedings of the National Academy of Sciences of the United States of Americano. 35 (2024): e2410206121-e2410206121
Proceedings of the National Academy of Sciences of the United States of Americano. 38 (2024): e2407325121-e2407325121
Dian Ding,Ziyuan Fang,Seohyun Chris Kim,Derek K. O'Flaherty,Xiwen Jia, Talbot B. Stone,Lijun Zhou,Jack W. Szostak
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 6 (2024): 3861-3871
Chemistry Challenges of the 21st Centurypp.445-451, (2024)
Aleksandar Radakovic,Anna Lewicka,Marco Todisco,Harry R. M. Aitken,Zoe Weiss, Shannon Kim, Abdullah Bannan,Joseph A. Piccirilli,Jack W. Szostak
bioRxiv the preprint server for biology (2024)
Journal of the American Chemical Societyno. 23 (2024): 15897-15907
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Author Statistics
#Papers: 511
#Citation: 55081
H-Index: 116
G-Index: 229
Sociability: 7
Diversity: 0
Activity: 3
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