My primary interest is the exploration of asthma through the use of animal and cellular models. The mechanisms of airway remodeling, the structural changes identified in asthmatic airways, are being investigated. In particular, the role of the epidermal growth factor receptor and the direct effect of T lymphocyte interaction with smooth muscle are being explored. The laboratory is addressing the effects of chlorine in airway dysfunction with particular interest in innate lymphoid cells and cysteinyl leukotrienes.