He addressed a wide variety of problems and applications at the macroscopic level, including endovascular techniques to induce and control mild hypothermia, unsteady blood flows, and the risk of rupture of aortic and intracranial arterial aneurysms. More recently, his work encompassed cerebrospinal flow in the central nervous system and its role in intrathecal drug delivery procedures. His contributions are equally important at the cellular level, including development of a novel three-dimensional cell-traction-force microscopy method and resolution of some of the biochemical pathways for the generation of traction forces exerted by cells during migration.