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Dr. Ivan Hirsch is a head of Department of Genetics and Microbiology at the Charles University in Prague, from where he graduated in biophysics in 1978, and where he returned as virologist after his twenty five-year career as a research director at INSERM in Marseille, France. He developed his love for viruses and their etiological role in cancer during his postdoctoral stay at the Department of Virology and Epidemiology at the Baylor College of Medicine in Houston, TX, and in the institute of Serum and Vaccine in Prague. In France he focused his research interest on HIV pathogenesis and latency. His work showed that CpG methylation of HIV-1 promoter is not required for the initial provirus silencing but it controls resistance of latent HIV-1 to reactivation signals and thus determines the stability of the HIV-1 latent reservoir. He also demonstrated accumulation of defective virus genomes in HIV-infected individuals and in macaques experimentally infected with SIV. Then, still in the INSERM laboratory in Marseille, and later on during his stay at the NICHD, NIH, Bethesda, MD and during the last 6 years with his group at the Faculty of sciences, Biocev, Prague, and in the Institute of Organic Chemistry and Biochemistry ASCR and in the Institute of molecular genetics ASCR in Prague he has studied interaction of viruses with the innate immunity system. He showed that binding of some viruses involved in chronic infections, such as HIV, hepatitis B and C viruses, to regulatory receptors of plasmacytoid dendritic cells inhibits activation of TLR7/9, and is an important mechanism suppressing the innate immunity responses.
研究兴趣
论文共 131 篇作者统计合作学者相似作者
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Cancersno. 9 (2021): 2076-2076
Frontiers in immunology (2018)
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#Papers: 131
#Citation: 3504
H-Index: 32
G-Index: 53
Sociability: 6
Diversity: 4
Activity: 6
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