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The Brierley lab., in close collaboration with the group of Dr Andrew Firth, study the regulation of virus gene expression at the level of protein synthesis, especially the phenomenon of ribosomal frameshifting. During translation, ribosomes generally stay in register and decode each codon triplet by triplet. However, some viral mRNAs have embedded signals that instruct ribosomes to change register, ie: to frameshift, at a defined position and to continue translation in an overlapping reading frame. Frameshift signals are exploited by many viruses to co-ordinate gene expression from overlapping coding sequences. The best studied examples come from the retroviruses. Here, the coding region for the enzymatic functions of the virus (pol) often overlaps the upstream structural protein coding sequences (gag) and is in the -1 reading frame. Expression of the pol gene requires a -1 frameshift at the end of gag and the Pol protein is produced as a fusion with the Gag protein. Our aim is to understand the frameshift process with a view to inhibiting it and thus to prevent virus replication. Many other RNA viruses have been shown to utilise a frameshift strategy in their replication cycle and there are emerging examples in cellular genes. A closely related translational phenomenon, termination codon suppression (readthrough), has also been described. Here, viral mRNA signals cause the misreading of stop codons, and an amino acid is inserted instead, at a certain frequency, resulting in an elongated polypeptide.
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论文共 69 篇作者统计合作学者相似作者
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Scientific reportsno. 1 (2023)
Elizabeth Sloan,Marta Alenquer,Liliane Chung,Sara Clohisey,Adam M. Dinan,Robert Gifford,Quan Gu,Nerea Irigoyen,Joshua D. Jones,Ingeborg van Knippenberg,Veronica Rezelj, Bo Wang,Helen M. Wise,Maria Joao Amorim,J Kenneth Baillie,Ian Brierley,Paul Digard,Andrew E. Firth,Megan K. MacLeod,Edward Hutchinson
bioRxiv (2019)
Access Microbiologyno. 1A (2019)
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#Papers: 69
#Citation: 5093
H-Index: 32
G-Index: 32
Sociability: 5
Diversity: 3
Activity: 5
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