基本信息
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职业迁徙
个人简介
Herman Overkleeft is an organic chemist and chemical biologist whose activity-based protein profiling (ABPP) program (Acc Chem Res 2011, 718) is recognized as leading internationally. His lab was the first (coinciding with the Cravatt group) to connect ABPP with bioorthogonal chemistry (van Swieten, Angew Chem Int Ed 2003) and the first to perform three bioorthogonal reactions in a single experiment (Willems, Angew Chem Int Ed 2012). His lab developed a chemoselective linker for chemical proteomics profiling (Geurink, Angew Chem Int Ed, 2009), and lysosomal cysteine protease (cathepsin) ABPs targeted to cells through the mannose receptor (Hillaert, Angew Chem Int Ed, 2010) and the M6P receptor (Hoogendoorn, Angew Chem Int Ed, 2014). The developed inhibitors and activity-based probes are highly sought-after commodities both for application in biomedicine and biotechnology studies. This has led to numerous fruitful collaborations, and to weekly shipments of compounds without strings attached to interested colleagues.
A main focus throughout the years has been the development of inhibitors and activity-based probes for human constitutive proteasomes and immunoproteasomes. This has resulted in a unique set of reagents and tools with which each of the six catalytic activities of the human constitutive proteasome and immunoproteasome combined can be inhibited and visualized (van Swieten, Angew Chem Int Ed 2003; de Bruin, Angew Chem Int Ed 2016; de Bruin, J Am Chem Soc 2016). Key collaborators on proteasome research are Alexei Kisselev (Auburn University, Alabama, USA; biochemistry, enzymology), Michael Groll (Technical University Munich, Germany; enzymology, structural biology) and Christoph Driessen (St Gallen Medical Centre, Switzerland; onco-haematology).
A main focus throughout the years has been the development of inhibitors and activity-based probes for human constitutive proteasomes and immunoproteasomes. This has resulted in a unique set of reagents and tools with which each of the six catalytic activities of the human constitutive proteasome and immunoproteasome combined can be inhibited and visualized (van Swieten, Angew Chem Int Ed 2003; de Bruin, Angew Chem Int Ed 2016; de Bruin, J Am Chem Soc 2016). Key collaborators on proteasome research are Alexei Kisselev (Auburn University, Alabama, USA; biochemistry, enzymology), Michael Groll (Technical University Munich, Germany; enzymology, structural biology) and Christoph Driessen (St Gallen Medical Centre, Switzerland; onco-haematology).
研究兴趣
论文共 844 篇作者统计合作学者相似作者
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Melissa Thaler,Tim P. Ofman,Ken Kok, Jurriaan J. A. Heming, Elisha Moran, Isabelle Pickles, Anouk A. Leijs,Adrianus M. C. H. van den Nieuwendijk, Richard J. B. H. N. van den Berg,Gijs Ruijgrok,Zachary Armstrong,Clarisse Salgado-Benvindo, Dennis K. Ninaber,Eric J. Snijder, Constant A. A. van Boeckel, Marta Artola,Gideon J. Davies,Herman S. Overkleeft,Martijn J. van Hemert
ACS central scienceno. 8 (2024): 1594-1608
Chemistry (Weinheim an der Bergstrasse, Germany)no. 31 (2024): e202400723-e202400723
Sander B. Engelsma,Aurelio Pio Nardozza, Pieter de Saint Aulaire,Herman S. Overkleeft,Gijsbert A. van Der Marel,Andreas G. Ladurner,Dmitri V. Filippov
ChemBioChemno. 8 (2024)
Tim P. Ofman, Jurriaan J. A. Heming,Alba Nin‐Hill,Florian Küllmer, Edmund J. Moran,Megan Bennett, Roy Steneker, Andreas R. Klein,Gijs Ruijgrok,Ken Kok,Zachary Armstrong,Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Carme Rovira, G.J. Davies, Marta Artola,Jeroen D. C. Codée,Herman S. Overkleeft
Chemistry (2024)
Marta Artola, Johannes M F G Aerts, Gijsbert A van der Marel,Carme Rovira,Jeroen D C Codée,Gideon J Davies,Herman S Overkleeft
Journal of the American Chemical Societyno. 36 (2024): 24729-24741
Chemistry – A European Journalpp.e202400723-e202400723, (2024)
Tim P. Ofman,Jurriaan J. A. Heming,Alba Nin-Hill, Florian Kuellmer,Elisha Moran,Megan Bennett,Roy Steneker, Anne-Mei Klein,Gijs Ruijgrok,Ken Kok,Zach W. B. Armstrong, Johannes M. F. G. Aerts,Gijsbert A. van Der Marel,Carme Rovira,Gideon J. Davies,Marta Artola,Jeroen D. C. Codee,Herman S. Overkleeft
CHEMISTRY-A EUROPEAN JOURNAL (2024)
Qin Su, Max Louwerse, Rob F Lammers, Elmer Maurits, Max Janssen, Rolf G Boot,Valentina Borlandelli,Wendy A Offen, Daniël Linzel,Sybrin P Schröder,Gideon J Davies,Herman S Overkleeft, Marta Artola,Johannes M F G Aerts
Chemical science (2024)
Zirui Li,Isabelle B. Pickles,Mahima Sharma, Benjamin Melling, Luise Pallasdies,Jeroen D. C. Codee,Spencer J. Williams,Herman S. Overkleeft,Gideon J. Davies
Joshua B. Simpson,Morgan E. Walker, Joshua J. Sekela, Samantha M. Ivey,Parth B. Jariwala, Cameron M. Storch,Mark E. Kowalewski,Amanda L. Graboski,Adam D. Lietzan,William G. Walton, Kacey A. Davis,Erica W. Cloer,Valentina Borlandelli,Yun-Chung Hsiao,Lee R. Roberts,David H. Perlman,Xue Liang,Hermen S. Overkleeft,Aadra P. Bhatt,Kun Lu, Matthew R. Redinbo
Cell host & microbe (2024)
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作者统计
#Papers: 844
#Citation: 24069
H-Index: 74
G-Index: 112
Sociability: 8
Diversity: 0
Activity: 6
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