Research
Genes interact in functional gene programs that ultimately constitute health or disease. Gene programs act on the level of individual cells but importantly also at tissue level across multiple cell types. Functionally connected multicellular circuits react as a coordinated unit in immunological responses to environmental challenges and infections. The main aim of this research is to understand how cells are wired together into circuits and thereby influence each other in lung health and disease. We study patient and mouse tissues, and organotypic ex vivo models at single cell resolution. This enables us to reconstruct regulatory cellular circuits and identify fundamental cellular and molecular mechanism of lung disease and regeneration, as well as associated clinically relevant biomarkers.