His research interests include statistics, image science, bioinformatics, data science, machine learning and artificial intelligence. He analyzes different types of data by developing statistical methodologies for machine learning with the power of statistical inference and computation algorithms. The research results have been published in a wide spectrum of journals and conferences. He co-edited the two editions of Handbook of Statistical Bioinformatics and Handbook of Big Data Analytics published by Springer in 2011, 2022 and 2018.