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We are interested in the unusual properties of FBPs, and have focussed much of our efforts on Fbxo7, the best example of this type of FBP. We identified Fbxo7 as an assembly factor for the proto-oncogenic D-type cyclin/Cdk6 activity. This suggested Fbxo7 would also have oncogenic activity, which we showed was the case in T lymphocytes. Upon further study, we found that Fbxo7 activity with regard to cell cycle regulation is exquisitely cell-type specific, and it can also behave as a tumour suppressor. As a regulator of cell cycle, Fbxo7 also affects cellular differentiation, and we currently investigate its impact on this in a number of different cell lineages, including haematopoietic cells and neurons. Recessive point mutations in Fbxo7 cause an atypical, early-onset form of Parkinson’s disease, and we are also characterising the defects that arise in neurons harbouring these mutated forms of Fbxo7. We also study other FBPs, including Fbxl17 and Fbxl20, which are among the most frequently rearranged genes in epithelial cancers. The challenge we face is to understand the different, complex functions of this family of signal transducing effector proteins in the context of both development and disease. We aim to tease out the cellular pathways regulated by them that can be influenced to benefit patients.
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论文共 52 篇作者统计合作学者相似作者
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Sophie E. Willis,Gemma N. Jones, Shaan Gill,Emma V. Jones,Amelia Raymond,Barrett Nuttall, Sophie Kirschner,Sakshi Gulati,Paola Marco-Casanova,Benedetta Lombardi,David Jenkins, Felicia S. Ng,James Hadfield,Paul Waring,Helen K. Angell,Heike Laman
Cancer Researchno. 6_Supplement (2024): 1649-1649
Molecular Cellno. 6 (2022): 1123-1139.e8
Valentine Spagnol,Caio A. B. Oliveira,Suzanne J. Randle,Patricia M. S. Passos, Camila R. S. T. B. Correia, Natalia B. Simaroli, Joice S. Oliveira,Tycho E. T. Mevissen,Ana Carla Medeiros,Marcelo D. Gomes,David Komander,Heike Laman,Felipe Roberti Teixeira
bioRxiv (Cold Spring Harbor Laboratory) (2019)
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#Papers: 52
#Citation: 1856
H-Index: 24
G-Index: 43
Sociability: 5
Diversity: 0
Activity: 0
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