Heidi R Hope - Confluence Discovery Technol Inc

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论文共 12 篇作者统计合作学者相似作者

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ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis Without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201

Paul Changelian,Canxin Xu,Steve Mnich,Heidi Hope,Kourtney Kostecki,Jeff Hirsch, Chin-Yi Loh,David Anderson, James Blinn,Susan Hockerman, Evan Dick,Walter Smith,Joseph Monahan, Tooraj Raoof, Seth Forman,David Burt, Brad Barnes,David Gordon,Neal Walker, John Sudzina

JID Innovationsno. 2 (2024): 100251

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ATI-450: A Novel MK2 Pathway Inhibitor - Preclinical & Clinical Translational Studies to Predict Human Dose

Heidi R. Hope,Susan Hockerman, Matt Saabye, Loreen Stillwell, Rakesh Basavalingappa, Catherine Emanual,Steve Mnich, Madison Bangs, Emma Huff, Aparna Kaul, Anne Hildebrand,Marco Cardillo,Ajay Aggarwal,Joseph B. Monahan

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)

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ATI-450, an Investigational MK2 Inhibitor, Is Well Tolerated and Demonstrated Clinical Activity in Patients with Mod/severe RA: A 12-week Phase 2a, Randomized, Investigator/patient-blind Study Investigating the Safety, Tolerability, PK and PD of ATI-450+MTX vs PBO plus MTX in MTX IR Patients

Alan Kivitz, Joe Monahan,David Burt,Marco Cardillo,Heidi Hope,David Gordon

ARTHRITIS & RHEUMATOLOGY（2021）

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MK2 Inhibitor ATI-450 in Healthy Subjects: A Placebo-Controlled, Randomized Phase I Study

David Gordon,Edward T. Hellriegel,Heidi Rath Hope,David Burt,Joseph B. Monahan

Clinical Pharmacology Advances and Applications（2021）

引用11浏览0WOS引用

Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals

Chun Wang,Susan Hockerman,E Jon Jacobsen,Yael Alippe,Shaun R Selness,Heidi R Hope,Jeffrey L Hirsch,Stephen J Mnich,Matthew J Saabye,William F Hood,Sheri L Bonar,Yousef Abu-Amer,Ariela Haimovich,Hal M Hoffman,Joseph B Monahan,Gabriel Mbalaviele

JOURNAL OF EXPERIMENTAL MEDICINE（2018）

引用59浏览0WOS引用

Discovery of Clinical Candidate 1-{[(2S,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Journal of Medicinal Chemistry（2017）

引用108浏览0WOS引用

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Nomid-Associated Complications In Mice Are Prevented By Cdd-450, A Small Molecule Inhibitor Of The Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (Mk2) Pathway

Gabriel Mbalaviele,Chun Wang,Susan Hockerman,Jon Jacobsen,Jeff Hirsch,Steve Mnich,Heidi Hope, Matt Saabye,Hal Hoffman,Joseph Monahan

ARTHRITIS & RHEUMATOLOGY（2017）

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A selective p38 MAPK-MK2 axis inhibitor dampens inflammasome priming signals and causes remarkable efficacy in disease models

Chun Wang, Yael Allipe,Jianqiu Xiao,Susan Hockerman,Jon Jacobsen,Heidi Hope,Jeff Hirsch,Steve Mnich, Matt Saabye,Sheri Bonar,Hal Hoffman,Joseph Monahan,Gabriel Mbalaviele

JOURNAL OF BONE AND MINERAL RESEARCH（2017）

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Interleukin-1β-induced Interleukin-6 Production in A549 Cells is Mediated by Both Phosphatidylinositol 3-Kinase and Interleukin-1 Receptor-Associated Kinase-4

Hiroyuki Eda,Barry L. Burnette,Hideaki Shimada,Heidi R. Hope,Joseph B. Monahan

Cell biology international（2011）

引用24浏览0WOS引用

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