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Dr. Atamna's research is directed at understanding the mechanism of cellular senescence and to develop strategies to delay this process. He discovered the anti-senescence activity of diaminophenothiazines (e.g., methylene blue, MB), its effect on complex-IV, and mitochondrial biogenesis. MB prevented the age-related decline in cognitive function and muscle strength. Furthermore, Dr. Atamna studies on the mechanism of neurodegeneration of Alzheimer's disease (AD) identified a heme-binding domain in Amyloid-β, which may explain some of the cytopathologies of AD (e.g., decline in complex-IV). He is interested in developing novel therapeutic and diagnostic strategies to delay AD and cell senescence in hope to improve the quality of life with age.
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论文共 81 篇作者统计合作学者相似作者
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Sebastian Cano-Besquet, Mei Liang, Karina Smolyar,Jeff Chen, Colton Rosendahl, Anmol Shrestha, Ashley Choi, Nicholas Eremita,Vinh Nguyen,Hani Atamna, Shabana Masood,Joseph Dhahbi
JOURNAL OF GENERAL INTERNAL MEDICINE (2023): S131-S131
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NEUROLOGYno. 17 (2023)
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Joseph M. Dhahbi, Joe W. Chen,Supriya Bhupathy,Hani Atamna,Marcelo Borges Cavalcante,Tatiana D. Saccon,Allancer D. C. Nunes, Jeffrey B. Mason,Augusto Schneider,Michal M. Masternak
Journals of Gerontology Series A-biological Sciences and Medical Sciencesno. 9 (2021): 1561-1570
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