Frisch leads a multi-institutional effort to develop high-speed, large-area, low-cost photodetectors. Such detectors could be used in applications ranging from medical imaging to cargo scanning. The benefits of applying such detectors to positron-emission tomography (PET) include higher imaging quality than existing PET systems, while reducing patient radiation exposure. Frisch was a founding member of the team that discovered the top quark at Fermi National Accelerator Laboratory in 1995. His research interests have included the search for new states of matter, extra-spatial dimensions and dark matter particles. He is a fellow of the American Physical Society and a recipient of the University’s Quantrell Award for Excellence in Undergraduate Teaching and the Provost’s Teaching Award.