Hanne Winther Frederiksen

Name: Hanne Frederiksen Title: Cand. Scient, Ph.D. Born: September 2nd, 1963, Copenhagen Education 2004: PhD, Department of Life Sciences and Chemistry, Roskilde University 1999: Master of Science (MSc) in chemistry and molecular biology, Department of Life Sciences and Chemistry, Roskilde University 1982: Laboratory technician certification, Laboratory Technician School, Copenhagen Professional career Since 2006: Senior scientist and leader of the analytical chemistry laboratory, Dep. of Growth and Reproduction, Rigshospitalet, University of Copenhagen 2006: Scientist in the group of bioactive food components and vitamins at Department of Food Chemistry, Danish Institute for Food and Veterinary Research 2003-05: Post doc in the group of prevention and life style diseases, Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research 2000-03: PhD student at the EU-project: Heterocyclic Amines in cooked foods - Role in Human Health. Institute of Food Safety and Nutrition, Danish Institute for Food and Veterinary Research 1983-92: Laboratory Technician, the National Museum of Denmark 1982: Laboratory Technician, S. Dyrup and CO, Søborg, Denmark 1981-82: Laboratory Trainee, Technical University of Denmark and the National Museum of Denmark Scientific activities and research As senior scientist my primary research area since 2006 has been 1) development of advanced multiple LC-MS/MS methods for the analysis of steroid hormones and non-persistent endocrine disrupting chemicals (EDCs) in biological matrices and 2) human biomonitoring (HBM) and research on exposure to EDCs and their metabolic distribution, breakdown and excretion as well as interactions between EDCs and natural steroid hormones and other effects on human reproductive health and 3) development of human reference materials for steroid hormones based on LC-MS/MS measurements for use in the clinic and research projects. I participate in national as well as international research projects such as e.g. project leader in HBM studies for the National Centre on Endocrine Disrupters (cend.dk). Management As leader of the analytical chemistry laboratory at Dep. of Growth and Reproduction, I am overall responsible for development, operating and maintenance of all analytical methods based on LC-MS/MS technologies in the department. The laboratory analyzes more than 12.000 patient and research samples per year and cover over methods for steroid hormones, EDCs and peptide hormones including from 3 to 38 analytes per method. The laboratory is DANAK accredited and participates in inter-laboratory validation and control programs and serves as reference laboratory in international harmonized approach programs for HMB (HBM4EU). In general Member of the Hormone and Endocrine Disruptor Laboratory Group at the Dep. of Growth and Reproduction, Rigshospitalet Member of the editorial board (associated editor) for “International Journal of Hygiene and Environmental Health” (IJHEH) from May 2016. Guest editor on special issue of Andrology 2016 and Reproduction 2014. Frequent referee for more than 10 different international journals. Previous research activities My Previous research (2000-2006) has been focused on bioavailability, metabolism, DNA-adduct formation and excretion of toxic and carcinogenic compounds, as well as health promoting substances. Have expertise in synthesis of reference compounds, method development and chemical analysis using advanced LC-MS/MS technology