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职业迁徙
个人简介
My main research goal is to understand and be able to control how cells respond to stressful and harmful conditions, which are the underlying causes of many human diseases. To achieve this goal, I study cellular response to stress at the protein level and aim to characterize the different regulatory functions mediated by the ubiquitin-proteasome system (UPS), essential machinery involved in modulating protein dynamics. Ultimately, regulating specific UPS roles will provide new tools to increase cellular tolerance to a variety of environmental stresses, which is highly relevant for a variety of degenerative diseases. The main focus of my lab is to investigate the unprecedented regulation of translation mediated by ubiquitin. I laid the groundwork for this research investigating the ubiquitination response in the budding yeast Saccharomyces cerevisiae and we will explore the evolutionary conservation of this pathway and its function in neuronal cells. Our lab is excited to keep pushing the field forward and to use a combination of proteomics, genomics, and molecular methods to understand the mechanisms by which ubiquitin regulates translation, and ultimately, cellular response to stress.
研究兴趣
论文共 242 篇作者统计合作学者相似作者
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Ana Paula Serafini Poeta Silva,Guilherme Arruda Cezar,Edison Sousa Magalhaes, Kinath Rupasinghe, Srijita Chandra,Gustavo S. Silva,Marcelo Almeida,Bret Crim,Eric Burrough,Phillip Gauger,Christopher Siepker,Marta Mainenti,Michael Zeller,Rodger G. Main,Mary Thurn, Paulo Fioravante,Cesar Corzo,Albert Rovira,Hemant Naikare,Rob McGaughey,Franco Matias Ferreyra,Jamie Retallick,Jordan Gebhardt,Angela Pillatzki,Jon Greseth,Darren Kersey,Travis Clement,Jane Christopher-Hennings,Melanie Prarat, Ashley Johnson, Dennis Summers, Craig Bowen,Kenitra Hendrix, Joseph Boyle,Daniel Correia Lima Linhares,Giovani Trevisan
PLOS ONEno. 7 (2024)
AASV Annual Meeting
bioRxiv the preprint server for biology (2024)
PREVENTIVE VETERINARY MEDICINE (2024)
PREVENTIVE VETERINARY MEDICINE (2024)
PREVENTIVE VETERINARY MEDICINE (2024)
AASV Pre-Conference Seminars
FRONTIERS IN VETERINARY SCIENCE (2024)
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作者统计
#Papers: 243
#Citation: 3046
H-Index: 28
G-Index: 50
Sociability: 7
Diversity: 3
Activity: 23
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