Gottfried Baier
教授
Institute of Cell Genetics
Department for Pharmacology and Genetics, Medical University of Innsbruck;Christian Doppler Laboratory for Pharmacological Cancer Immunotherapy, Medical University of Innsbruck;Division for Translational Cell Genetics, Department for Pharmacology and Genetics, Medical University of Innsbruck;Institute for Translational Cell Genetics;Division for Cell Genetics, Medical University of Innsbruck
关注
立即认领
分享
关注
立即认领
分享
基本信息
浏览量:90
职业迁徙
个人简介
Research of his laboratory is focusing on molecular mechanisms signaling mediating tolerance induction versus clonal expansion of T lymphocyte. His team has initially focused on the physiological involvement of distinct PKC isotypes in specific immune cell functions, employing a set of single- and double PKC isotype gene
knockout mice as well as specific and potent low molecular weight inhibitors generated by his BigPharma and SME partners. His achievements include the leading-edge discoveries of the central-staged PKC/Cbl-b and
PKC/NR2F6 signaling pathways and their key role in the control of cancer immunity. Genetic blocking experiments have shown promising improvements in anti-tumour T cell responses, thereby validating particularly NR2F6 as an alternative and druggable cancer therapeutic candidate drug target for next-generation immune-oncology regimens.
knockout mice as well as specific and potent low molecular weight inhibitors generated by his BigPharma and SME partners. His achievements include the leading-edge discoveries of the central-staged PKC/Cbl-b and
PKC/NR2F6 signaling pathways and their key role in the control of cancer immunity. Genetic blocking experiments have shown promising improvements in anti-tumour T cell responses, thereby validating particularly NR2F6 as an alternative and druggable cancer therapeutic candidate drug target for next-generation immune-oncology regimens.
研究兴趣
论文共 182 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Biomoleculesno. 11 (2023): 1599-1599
Science advancesno. 27 (2023)
引用0浏览0WOS引用
0
0
Cancer immunology researchno. 4 (2022): 370-370
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn