His scientific interests lie mostly in Genetics, Glycosylation, Mutation, Molecular biology and Missense mutation. His Mutation, Haplotype, Genotype, Gene and Phosphomannomutase study are his primary interests in Genetics. The Glycosylation study combines topics in areas such as Golgi apparatus, Congenital disorder of glycosylation and Glycoprotein, Glycan. His study in Mutation is interdisciplinary in nature, drawing from both Hypotonia, Exon and Amyotrophic lateral sclerosis, SOD1. His research integrates issues of Long QT syndrome, KvLQT1, Potassium channel, GATA1 and Zinc finger in his study of Molecular biology. Gert Matthijs interconnects Germline mutation, Compound heterozygosity and Null allele in the investigation of issues within Missense mutation.