基本信息
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职业迁徙
个人简介
Research Interest
Blood research
Immunology
Inflammation
Effect of diet on cancer
Our lab is interested in both the effects of various diets on cancer (CA) incidence and in determining who is at risk of developing CA so we can prevent it by adopting life style changes. In regard to the first goal, since tumour cells are more dependent on blood glucose than normal cells for their growth, we have been testing low carbohydrate (CHO) diets on mice and found they reduce the incidence, growth rate and metastasis of primary tumours. Related to this, we have been studying ways to alter the properties of the immune cells within tumours to enhance their ability to kill the CA cells. Because many tumours secrete factors that subvert the ability of tumour-infiltrating immune cells to kill CA cells, we have been examining the effects of different immune modulating agents and found that low levels of non-steroidal anti-inflammatory drugs like Celebrex, in conjunction with our low CHO diets, dramatically reduce the growth rate of tumours.
In regard to the second goal, there is growing evidence that low levels of chronic inflammation (CI), i.e., below those manifesting in obvious disease, coupled with a poor immune response to viral infections increase the incidence of many human CAs. Thus the identification of individuals with low but detectable levels of CI and a poor anti-viral response would be of great value in indentifying high-risk people. As well, recent research has shown that what we eat determines the type of bacteria that reside in our gut (i.e., our gut microbiome) and these bacteria likely play an important role in determining our levels of CI. Lastly, macrophages (MФs), which are key immune cells in all our tissues, vary from person to person in their properties, from being skewed to very pro-inflammatory (M1 or killer MФs) in some people to very anti-inflammatory (M2 or healer MФs) in others, with most people being somewhere in between. Since MФs secrete many immune modulators, where on this spectrum a person’s MФs exist profoundly influences his/her level of CI and ability to fight off infections.
Blood research
Immunology
Inflammation
Effect of diet on cancer
Our lab is interested in both the effects of various diets on cancer (CA) incidence and in determining who is at risk of developing CA so we can prevent it by adopting life style changes. In regard to the first goal, since tumour cells are more dependent on blood glucose than normal cells for their growth, we have been testing low carbohydrate (CHO) diets on mice and found they reduce the incidence, growth rate and metastasis of primary tumours. Related to this, we have been studying ways to alter the properties of the immune cells within tumours to enhance their ability to kill the CA cells. Because many tumours secrete factors that subvert the ability of tumour-infiltrating immune cells to kill CA cells, we have been examining the effects of different immune modulating agents and found that low levels of non-steroidal anti-inflammatory drugs like Celebrex, in conjunction with our low CHO diets, dramatically reduce the growth rate of tumours.
In regard to the second goal, there is growing evidence that low levels of chronic inflammation (CI), i.e., below those manifesting in obvious disease, coupled with a poor immune response to viral infections increase the incidence of many human CAs. Thus the identification of individuals with low but detectable levels of CI and a poor anti-viral response would be of great value in indentifying high-risk people. As well, recent research has shown that what we eat determines the type of bacteria that reside in our gut (i.e., our gut microbiome) and these bacteria likely play an important role in determining our levels of CI. Lastly, macrophages (MФs), which are key immune cells in all our tissues, vary from person to person in their properties, from being skewed to very pro-inflammatory (M1 or killer MФs) in some people to very anti-inflammatory (M2 or healer MФs) in others, with most people being somewhere in between. Since MФs secrete many immune modulators, where on this spectrum a person’s MФs exist profoundly influences his/her level of CI and ability to fight off infections.
研究兴趣
论文共 343 篇作者统计合作学者相似作者
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 18 (2024)
Ingrid Elisia,Michelle Yeung,Sara Kowalski,Taras Shyp, Jason Tee, Serena Hollman, Amy Wong, Janette King,Roger Dyer,Poul H. Sorensen,Gerald Krystal
Scientific reportsno. 1 (2024)
Current Developments in Nutrition (2023)
Current Developments in Nutrition (2023): 101459-101459
Current Developments in Nutrition (2023): 100470-100470
Pharmacological Research - Modern Chinese Medicine (2023): 100328
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作者统计
#Papers: 342
#Citation: 15723
H-Index: 68
G-Index: 117
Sociability: 7
Diversity: 3
Activity: 22
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