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Dr. Narlikar studies how the folding and compartmentalization of our genome is regulated to generate the many cell types that make up our body. Her laboratory has pioneered the application of sophisticated biophysical approaches to study the mechanisms of macromolecules that regulate genome organization. Through these studies they are learning (i) how nanoscale molecular motors use chemical energy to cause mechanical disruptions in the packaged genome, (ii) that the smallest unit of genome folding, a nucleosome, acts akin to a dynamic receptor rather than a static packaging unit and, (iii) that liquid-liquid phase separation processes can help organize and sequester large regions of the genome. These types of discoveries from the Narlikar laboratory are changing textbook descriptions of genome packaging and suggesting new avenues to tackle diseases caused by defects in genome organization.
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Science (New York, N.Y.)no. 6655 (2023): 319-324
Ziling Kate Zhou,Geeta J Narlikar
bioRxiv : the preprint server for biology (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 18 (2023)
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Molecular cellno. 11 (2022): 2098-2112.e4
Biophysical Journalno. 11 (2022): 2098-2112.e4
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