Metabolic pathways in plants are quite dynamic, resulting in production of over a million metabolites across ~300,000 estimated plant species. These metabolic pathways are in a constant state of innovation due to gene duplication, transcriptional divergence, enzyme promiscuity etc. How have specific metabolic pathways originated and diversified? What is the role of positive selection and genetic drift in shaping metabolic diversity? How does enzyme promiscuity influence evolution of specialized metabolic pathways? We are investigating these and other allied questions using evolutionary approaches, by performing comparative analyses of plant genomes, transcriptomes and metabolomes. Research in the Moghe lab is highly integrative and comprised of both computational and wet-lab approaches.