Gaelle Friocourt - GGB, Univ Brest | 人才画像

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Bio

We work on cortical development with a focus on ARX, a gene involved in the development of GABAergic neurons. Using mouse models and iPS technology, we study the role of this gene in cognitive and fine motor functions such as language and prehension. In another project, we are investigating the effect of cystathionine-beta synthase (CBS) overexpression in brain function. The gene dosage of this enzyme appears critical in homocystinuria and Down syndrome.

Research Interests

Papers共 53 篇Author StatisticsCo-AuthorSimilar Experts

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De Novo Variants in SP9 Cause a Novel Form of Interneuronopathy Characterized by Intellectual Disability, Autism Spectrum Disorder, and Epilepsy with Variable Expressivity

Marine Tessarech,Gaelle Friocourt,Florent Marguet,Maryline Lecointre,Morgane Le Mao, Rodrigo Munoz Diaz,Cyril Mignot,Boris Keren,Benedicte Heron,Charlotte De Bie,Koen Van Gassen,Didier Loisel,Benoit Delorme,Steffen Syrbe,Annick Klabunde-Cherwon,Rami Abou Jamra,Meret Wegler,Bert Callewaert,Annelies Dheedene, Merzouka Zidane-Marinnes, Agnes Guichet, Celine Bris, Patrick Van Bogaert, Florence Biquard, Guy Lenaers, Pascale Marcorelles, Claude Ferec, Bruno Gonzalez, Vincent Procaccio,Antonio Vitobello, Dominique Bonneau, Annie Laquerriere, Salim Khiati, Estelle Colin

Genetics in Medicineno. 5 (2024)

Cited0Views0WOSBibtex

New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome

Pierre Conan,Alice Leon,Noeline Caroff,Claire Rollet,Loubna Chair,Jennifer Martin,Frederic Bihel, Olivier Mignen,Cecile Voisset,Gaelle Friocourt

FRONTIERS IN NEUROSCIENCE (2023): 1110163

Cited1Views0WOSBibtex

Bypassing Mendel’s First Law: Transmission Ratio Distortion in Mammals

Gaëlle Friocourt,Aurore Perrin,Paul A. Saunders,Elvira Nikalayevich,Cécile Voisset,Charles Coutton,Guillaume Martinez,Frédéric Morel

International Journal of Molecular Sciencesno. 2 (2023): 1600

Cited0Views0Bibtex

Oligodendrocyte Lineage is Severely Affected in Human Alcohol-Exposed Foetuses

Florent Marguet,Mélanie Brosolo,Gaëlle Friocourt,Fanny Sauvestre,Pascale Marcorelles,Céline Lesueur,Stéphane Marret,Bruno J. Gonzalez,Annie Laquerrière

Acta Neuropathologica Communicationsno. 1 (2022)

Cited3Views0WOSBibtex

P53, A Victim of the Prion Fashion

Olivier Billant,Gaëlle Friocourt,Pierre Roux,Cécile Voisset

Cancersno. 2 (2021)

Cited7Views0WOSBibtex

Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation

Bamia Aline,Sinane Maha,Naït-Saïdi Rima,Dhiab Jamila,Keruzoré Marc, Bertho Agathe, University of Dundee, Univ. Lille,Blondel Marc,Trollet Capucine,Simonelig Martine,Friocourt Gaëlle,Béringue Vincent,Bihel Frédéric,Voisset Cécile

Neurotherapeutics（2021）

Cited5Views0WOSBibtex

Mechanism of Cystathionine-Β-synthase Inhibition by Disulfiram: the Role of Bis(n,n-Diethyldithiocarbamate)-copper(ii)

Karim Zuhra,Theodora Panagaki,Elisa B. Randi,Fiona Augsburger,Marc Blondel,Gaelle Friocourt,Yann Herault,Csaba Szabo

Biochemical pharmacology（2020）

Cited23Views0WOSBibtex

Cbs Overdosage is Necessary and Sufficient to Induce Cognitive Phenotypes in Mouse Models of Down Syndrome and Interacts Genetically with Dyrk1a

Damien Marechal,Veronique Brault,Alice Leon, Dehren Martin,Patricia Lopes Pereira,Nadege Loaec,Marie-Christine Birling,Gaelle Friocourt,Marc Blondel,Yann Herault

Human molecular genetics online/Human molecular genetics（2019）

Cited40Views0WOSBibtex

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