The main focus of the studies in my laboratory is the role of metal homeostasis in host-pathogen interactions. I am particularly interested in the effects of metal ion restriction, resulting from nutritional immunity, on the pathogenesis of M. tuberculosis (Mtb). My early training in biochemistry, cell biology, and immunology, combined with many years in the TB field have given me the right foundation to study the biology of the tuberculous bacillus, and the complex interplay between Mtb and its host.