基本信息
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职业迁徙
个人简介
Research Initiatives
Research in our laboratories focuses on the structure, regulation, mechanism
of action, and folding of two groups of enzymes. Our research on thiamin
diphosphate (the vitamin B1 coenzyme)-dependent enzymes has followed a dual
approach. Part of our group is studying how a-keto acid decarboxylascs work,
including both nonoxidative and oxidative functions. Questions being asked
include determining the 3-D struc-ture of the protein, the conformation and
activation of the coenzymes in catalysis, the nature of proton transfer events
in catalysis, and the mechanism of electron and group transfer in the oxidative
processes. Tools used in these studies include high resolution X-ray
crystallography (pyruvate decarboxylase, the simplest of these enzymes was
solved to a resolution of 2.3A), nuclear magnetic resonance spectroscopy,
molecular genetics to change amino acids in the structure to establish
structure-function relationships, steady-state and pre-steady-state kinetics,
and immunochemical methods. Our enzyme studies are being complemented with model organic chemical studies, in which the elementary steps of the multi-step enzymatic reactions are being modeled. From such chemical models, one can learn which step and by how much the enzyme must accelerate.
研究兴趣
论文共 452 篇作者统计合作学者相似作者
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期刊级别
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International journal of molecular sciencesno. 5 (2023): 4555-4555
Reactionsno. 1 (2022): 139-159
International journal of molecular sciencesno. 15 (2022): 8213-8213
bioRxiv (Cold Spring Harbor Laboratory) (2021)
BRAIN STRUCTURE & FUNCTIONno. 2 (2020): 639-667
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作者统计
#Papers: 451
#Citation: 11383
H-Index: 55
G-Index: 88
Sociability: 7
Diversity: 0
Activity: 1
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