Regarding his research career, he explored several fields of basic, translational, epidemiological and clinical research in PD. He contributed to dopaminergic neurotransmission chemical neuro-anatomy in basal ganglia, developed new animal models of atypical parkinsonism (nigrsotriatal degeneration). He also conducted epidemiological studies on PD and related disorders in population–based cohorts and coordinated as a PI or Co-PI academic and industry or foundations (MJFF)-sponsored clinical research studies on neuro-pharmacology, physiopathology and biomarkers of PD and AD. Today, more than 30 clinical research studies are running at the IMNc.