Francisco Leon

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The Mitragyna Speciosa (kratom) Alkaloid Mitragynine: Analysis of Adrenergic Α2 Receptor Activity in Vitro and in Vivo

Samuel Obeng,Morgan L. Crowley,Marco Mottinelli,Francisco Leon,Julio D. Zuarth Gonzalez,Yiming Chen,Lea R. Gamez-Jimenez,Luis F. Restrepo,Nicholas P. Ho,Avi Patel, Joelma Martins Rocha, Manuel A. Alvarez, Amsha M. Thadisetti, Chai R. Park,Victoria L. C. Pallares, Megan J. Milner,Clinton E. Canal,Aidan J. Hampson,Christopher R. McCurdy,Lance R. McMahon,Jenny L. Wilkerson,Takato Hiranita

European Journal of Pharmacologypp.176863-176863, (2024)

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Synthesis and Monoamine Oxidase Inhibitory Activity of Halogenated Flavones

Jorge I. Castillo-Arellano, Zachary Stryker,Michael D. Wyatt,Francisco Leon

ACS Medicinal Chemistry Lettersno. 5 (2024): 610-618

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Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats

Shyam H. Kamble,Samuel Obeng,Francisco Leon,Luis F. Restrepo,Tamara I. King,Erin C. Berthold,Siva Rama Raju Kanumuri,Lea R. Gamez-Jimenez,Victoria L. C. Pallares,Avi Patel,Nicholas P. Ho,Aidan Hampson,Christopher R. McCurdy,Lance R. McMahon,Jenny L. Wilkerson,Abhisheak Sharma,Takato Hiranita

Journal of Pharmacology and Experimental Therapeuticsno. 3 (2023): 180-192

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Directed Biosynthesis of Mitragynine Stereoisomers

Carsten Schotte,Yindi Jiang,Dagny Grzech,Thu-Thuy T. Dang,Larissa C. Laforest,Francisco Leon,Marco Mottinelli,Satya Swathi Nadakuduti,Christopher R. McCurdy,Sarah E. O'Connor

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY（2023）

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Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer

Elena Spinola-Lasso,Juan Carlos Montero,Roberto Jimenez-Monzon,Francisco Estevez,Jose Quintana,Borja Guerra,Khaled M. Elokely,Francisco Leon,Henoc del Rosario,Leandro Fernandez-Perez, Manuel Rodriguez Lopez,Bonifacio Nicolas Diaz-Chico,Grant McNaughton-Smith,Atanasio Pandiella,Juan Carlos Diaz-Chico

International Journal of Biological Sciencesno. 6 (2023): 1731-1747

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Natural Corynanthe-Type Cholinesterase Inhibitors from Malaysian Uncaria attenuata Korth.: Isolation, Characterization, In Vitro and In Silico Studies

Nelson Jeng-Yeou Chear, Tan Ai Fein Ching-Ga,Kooi-Yeong Khaw,Francisco Leon,Wen-Nee Tan,Siti R. R. Yusof,Christopher R. R. McCurdy,Vikneswaran Murugaiyah,Surash Ramanathan

Metabolitesno. 3 (2023): 390-390

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Therapeutics to Treat Psychiatric and Neurological Disorders: A Promising Perspective from Algerian Traditional Medicine

Farida Larit,Francisco Leon

Plants (Basel, Switzerland)no. 22 (2023)

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Cannabidiol and Mitragynine Exhibit Differential Interactive Effects in the Attenuation of Paclitaxel-Induced Mechanical Allodynia, Acute Antinociception, and Schedule-Controlled Responding in Mice

Yuma T. Ortiz,Christopher R. McCurdy,Francisco León,Jenny L. Wilkerson

Journal of Painno. 4 (2023): 45-46

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The Polypharmacological Effects of Cannabidiol

Jorge Castillo-Arellano,Ana Canseco-Alba,Stephen J. Cutler,Francisco León

Molecules（2023）

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Interactive Effects of -Opioid and Adrenergic-₂ Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine (vol 383, pg 182, 2022)

Samuel Obeng,Francisco Leon,Avi Patel,Julio D. Gonzalez Zuarth,Lucas Chaves Da Silva,Luis F. Restrepo,Lea R. Gamez-Jimenez,Nicholas P. Ho,Maria P. Calvache Guerrero,Victoria L. C. Pallares, Justin A. Helmes,Sakura K. Shiomitsu,Paul L. Soto,Aidan J. Hampson,Christopher R. McCurdy,Lance R. McMahon,Jenny L. Wilkerson,Takato Hiranita

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICSno. 2 (2023): 326-326

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