Frances Skinner has strong research interests in creating bidirectional links between models and experiments. The work in her lab involves: (i) establishing intimate links with experimental studies to allow mathematical models with a neurological and pathophysiological functional basis to be developed, and (ii) simulating and analyzing developed mathematical models to enable insights and predictions to emerge. At present, there is a strong focus on the hippocampus, with a specialization on inhibitory GABAergic cells, and in the context of physiologically relevant population activity outputs of theta and gamma rhythms. This is being expanded to include the cortex. Inhibitory cells and networks have been found to play critical roles in learning and memory as well as in pathological conditions such as epilepsy and Alzheimer’s disease. The work is highly inter-disciplinary and collaborative by nature.