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Dr. Teles’ interests include the study of the oral microbiome in health, disease initiation, progression and in response to periodontal treatment and implant placement as well as the investigation of the microbial ecology of the oral cavity. For the past ten years, her research activities in the have been supported by grants from NIH/NIDCR, industry and foundations.
Dr. Teles’ main line of research is dedicated to the identification and cultivation of new periodontal pathogens using state-of-the-art cultivation and molecular approaches. Even though uncultivated/unrecognized organisms comprise 50% of the oral microbiome, their role in periodontal health and disease is unknown and will only be fully realized once they are cultivated and characterized. In addition, the study of these new bacterial species may lead to the discovery of new compounds and metabolic pathways, which can foster the development of better strategies for prevention and treatment of periodontal diseases as well as other oral conditions. Our lab developed in vitro and ex vivo (i.e., obtained from patient samples) biofilm models that give us the ability to foster the cultivation of difficult to grow microorganisms and to test new antimicrobials and the antimicrobial mechanisms of anti-infective periodontal therapies.
Dr. Teles research program also explores the association between the oral microbiome and carcinogenesis. Since several bacterial species can synthesize carcinogenic compounds and the oral cavity harbors a diverse and complex microbiota, the oral microbiome might contribute to the development of head and neck cancers. Thus, as part of a grant awarded by the Fanconi Anemia Research Fund, Dr. Teles have been investigating the oral microbiome, as well as the oral inflammatory and metabolic profiles of children and young adults with Fanconi Anemia (FA). FA is a rare genetic disorder that leads to increased oral cancer predisposition (as well other malignancies) due to hypersensitivity to DNA damage. Thus, the identification of the determinants of oral carcinogenesis in this population may provide key insights into mechanisms of oral cancer development in FA patients as well as in the general population.
For Dr. Teles, this is a particularly exciting time to be a microbiologist, as cutting-edge, high-throughput sequencing technologies and bioinformatics tools are becoming increasingly available. However, new technologies also bring challenges and new platforms need to be validated. In the past two years, the Teles lab have been conducting validation studies using a mock community of 40 bacterial reference strains to assess the precision and accuracy of several aspects of 16S rRNA sequencing and metagenomics, including the use of different primers ad sequencing cores, and the associated analytical tools.
In the next phase of Dr. Teles’ research program, she will explore new and affordable periodontal therapies and to expand my work her work on oral carcinogenesis to include mechanistic projects as well as clinical longitudinal studies of populations at risk for oral cancer.
Dr. Teles’ main line of research is dedicated to the identification and cultivation of new periodontal pathogens using state-of-the-art cultivation and molecular approaches. Even though uncultivated/unrecognized organisms comprise 50% of the oral microbiome, their role in periodontal health and disease is unknown and will only be fully realized once they are cultivated and characterized. In addition, the study of these new bacterial species may lead to the discovery of new compounds and metabolic pathways, which can foster the development of better strategies for prevention and treatment of periodontal diseases as well as other oral conditions. Our lab developed in vitro and ex vivo (i.e., obtained from patient samples) biofilm models that give us the ability to foster the cultivation of difficult to grow microorganisms and to test new antimicrobials and the antimicrobial mechanisms of anti-infective periodontal therapies.
Dr. Teles research program also explores the association between the oral microbiome and carcinogenesis. Since several bacterial species can synthesize carcinogenic compounds and the oral cavity harbors a diverse and complex microbiota, the oral microbiome might contribute to the development of head and neck cancers. Thus, as part of a grant awarded by the Fanconi Anemia Research Fund, Dr. Teles have been investigating the oral microbiome, as well as the oral inflammatory and metabolic profiles of children and young adults with Fanconi Anemia (FA). FA is a rare genetic disorder that leads to increased oral cancer predisposition (as well other malignancies) due to hypersensitivity to DNA damage. Thus, the identification of the determinants of oral carcinogenesis in this population may provide key insights into mechanisms of oral cancer development in FA patients as well as in the general population.
For Dr. Teles, this is a particularly exciting time to be a microbiologist, as cutting-edge, high-throughput sequencing technologies and bioinformatics tools are becoming increasingly available. However, new technologies also bring challenges and new platforms need to be validated. In the past two years, the Teles lab have been conducting validation studies using a mock community of 40 bacterial reference strains to assess the precision and accuracy of several aspects of 16S rRNA sequencing and metagenomics, including the use of different primers ad sequencing cores, and the associated analytical tools.
In the next phase of Dr. Teles’ research program, she will explore new and affordable periodontal therapies and to expand my work her work on oral carcinogenesis to include mechanistic projects as well as clinical longitudinal studies of populations at risk for oral cancer.
研究兴趣
论文共 55 篇作者统计合作学者相似作者
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Nidia Castro Dos Santos, Miriam R Westphal,Belen Retamal-Valdes,Poliana Mendes Duarte,Luciene Cristina Figueiredo,Marcelo Faveri, Jamil Shibli,Geisla Soares, Tamires Miranda,Daiane Fermiano, Ivan Borges,Cristiane Goncalves,
Journal of periodontal research (2024)
JNCI cancer spectrumno. 3 (2023)
Bruno S. Herrera, Sandra L. Henz,Shawn Dua,Lynn Martin,Ricardo P. Teles,Michele Patel,Flavia R.F. Teles
Archives of Oral Biology (2023): 105721-105721
INTERNATIONAL JOURNAL OF CANCERno. 2 (2023): 302-311
Journal of clinical periodontology (2023)
Journal of clinical periodontologyno. 9 (2023): 1140-1153
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