基本信息
浏览量:5
职业迁徙
个人简介
Research and Professional Interests:
My laboratory studies Kaposi’s sarcoma–associated herpesvirus (KSHV), a human DNA tumor virus associated with several human malignancies, including Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. We are interested in viral proteins that are localized in the tegument layer, a space between capsid and envelope in the viral particles. The tegument comprises at least a dozen proteins that are delivered into cells upon infection, so they have the opportunity to exert their functions at the very beginning in the infection process. The unique temporal and spatial expressions of tegument proteins put them in the forefront of coping with the host cellular environment. We found that KSHV ORF45, an abundant gammaherpesvirus-specific tegument protein, interacts with interferon regulatory factor 7 (IRF-7) and antagonizes the host innate antiviral responses. We also revealed that ORF45 interacts with p90 ribosomal S6 kinases (RSKs) and modulates the ERK/RSK MAPK signaling pathway, which plays critical roles in KSHV lytic replication. More recently, we discovered ORF52, another abundant gammaherpesvirus-specific tegument protein, as the first viral inhibitor of the host major cytosolic DNA sensor cGAS (cyclic GMP-AMP synthase). We therefore proposed to rename it KicGAS (KSHV inhibitor of cGAS). We are now exploring the mechanisms by which these KSHV tegument proteins evade the host innate antiviral responses and modulate the host intracellular kinase signaling pathways. We are also interested in the structural analysis of herpesvirus tegument by CryoEM. The structural organization and morphogenesis of herpesviral tegument are largely unknown. We use various approaches to investigate why and how viral proteins are selectively assembled into the tegument layer.
My laboratory studies Kaposi’s sarcoma–associated herpesvirus (KSHV), a human DNA tumor virus associated with several human malignancies, including Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. We are interested in viral proteins that are localized in the tegument layer, a space between capsid and envelope in the viral particles. The tegument comprises at least a dozen proteins that are delivered into cells upon infection, so they have the opportunity to exert their functions at the very beginning in the infection process. The unique temporal and spatial expressions of tegument proteins put them in the forefront of coping with the host cellular environment. We found that KSHV ORF45, an abundant gammaherpesvirus-specific tegument protein, interacts with interferon regulatory factor 7 (IRF-7) and antagonizes the host innate antiviral responses. We also revealed that ORF45 interacts with p90 ribosomal S6 kinases (RSKs) and modulates the ERK/RSK MAPK signaling pathway, which plays critical roles in KSHV lytic replication. More recently, we discovered ORF52, another abundant gammaherpesvirus-specific tegument protein, as the first viral inhibitor of the host major cytosolic DNA sensor cGAS (cyclic GMP-AMP synthase). We therefore proposed to rename it KicGAS (KSHV inhibitor of cGAS). We are now exploring the mechanisms by which these KSHV tegument proteins evade the host innate antiviral responses and modulate the host intracellular kinase signaling pathways. We are also interested in the structural analysis of herpesvirus tegument by CryoEM. The structural organization and morphogenesis of herpesviral tegument are largely unknown. We use various approaches to investigate why and how viral proteins are selectively assembled into the tegument layer.
研究兴趣
论文共 69 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Tracey N. Bell,Aubrey E. Kusi-Appiah, Vincent Tocci, Pengfei Lyu, Lei Zhu,Fanxiu Zhu,David Van Winkle,Hongyuan Cao, Mandip S. Singh,Steven Lenhert
PLOS ONEno. 7 (2024)
Journal of biological chemistry/The Journal of biological chemistryno. 3 (2023): 102986-102986
Journal of medical virologyno. 3 (2023)
Nature communicationsno. 1 (2022): 472-472
加载更多
作者统计
#Papers: 69
#Citation: 3089
H-Index: 30
G-Index: 55
Sociability: 6
Diversity: 3
Activity: 26
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn