Research Interests
Antifungal peptides
Invasive fungal infections are difficult to treat, and many current drugs are toxic to human cells, resulting in severe side effects including chronic kidney damage. There are various peptides isolated from natural sources that show potent antifungal activity and might be useful for developing less toxic antifungal treatments. In this project we combine computer simulations and various wet-lab experiments to study how these peptides interact with model and fungal membranes. The project is a collaboration with researchers from the University of Technology Sydney and the University of Sydney.
Pore forming peptide (viroporins and antimicrobial peptides)
Peptides that self-assemble that induce pores in membranes are ubiquitous in biology. Examples include antimicrobial peptides found in our innate immune systems or viroporins used by viruses to facilitate the release of viral particles from infected cells. In this project we combine computer simulations and various wet-lab experiments to characterise the structure and ion selectivity of such pore forming peptides.
Steroid – membrane interactions
Steroids are a class of chemical compounds that occur naturally in the body (e.g. progesterone or testosterone) and are also used to treat a range of conditions such asthma, eczema or arthritis. Steroids exert their biological or pharmacological activities via a range of different mechanism, including by altering the structure and fluidity of cell membranes. We combine computer simulations and various wet-lab experiments to understand how steroids interact with membranes and how this might be used to modulate the function of membrane proteins. This project is a collaboration with researchers from the University of Technology Sydney and the University of Sydney.
Metal-binding proteins and their role in bacterial infections
Bacteria use a range of different proteins to scavenge nutrients including metals from their host. Characterising the structure and function of bacterial metal-binding proteins is important for understanding bacterial pathogenesis and to develop strategies to prevent or reduce the spread of infections. This project is a collaboration with researchers from the University of Melbourne.