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职业迁徙
个人简介
The primary areas of the lab are:
A) To examine the mechanisms by which overall protein synthesis is shutoff in response to cellular stress. ER stress and hypoxia are common stresses that occur during the progression of diseases such as cancer and diabetes. By pinpointing the translational control mechanisms underlying these stresses, we will get a better understanding of how cells respond to stress and how these mechanisms may go awry during disease progression.
B) To identify mRNAs that are selectively translated during conditions when overall protein synthesis is shutoff and to elucidate how these specialized mRNAs can bypass the translational control block. Elucidating the translational control mechanisms of these specialized mRNAs is not only important for our overall understanding of gene expression during stress, but may also reveal novel targets for developing therapies against viral infections, stress and cancer.
A) To examine the mechanisms by which overall protein synthesis is shutoff in response to cellular stress. ER stress and hypoxia are common stresses that occur during the progression of diseases such as cancer and diabetes. By pinpointing the translational control mechanisms underlying these stresses, we will get a better understanding of how cells respond to stress and how these mechanisms may go awry during disease progression.
B) To identify mRNAs that are selectively translated during conditions when overall protein synthesis is shutoff and to elucidate how these specialized mRNAs can bypass the translational control block. Elucidating the translational control mechanisms of these specialized mRNAs is not only important for our overall understanding of gene expression during stress, but may also reveal novel targets for developing therapies against viral infections, stress and cancer.
研究兴趣
论文共 106 篇作者统计合作学者相似作者
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Yihang Chen, Subash Chapagain, Jodi Chien, Higor Sette Pereira,Trushar R. Patel, Alice K. Inoue-Nagata,Eric Jan
Virusesno. 5 (2024): 695
ACS nanono. 21 (2023): 22046-22059
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Irina S. Abaeva,Christina Young,Reid Warsaba, Nadiyah Khan, Lan Vy Tran,Eric Jan,Tatyana Pestova,Christopher U. T. Hellen
Nucleic acids researchno. 17 (2023): 9294-9313
Jerry Leung,Colton Strong, Katherine E. Badior,Madelaine Robertson,Xiaowu Wu,Michael A. Meledeo, Emma Kang, Manoj Paul,Yusuke Sato,Hideyoshi Harashima,Andrew P. Cap,Dana V. Devine,
Science advancesno. 48 (2023): eadi0508-eadi0508
Advanced materials (Deerfield Beach, Fla.)no. 31 (2023): e2303370-e2303370
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