基本信息
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职业迁徙
个人简介
The Elinav lab studies the microbiome, the immense microbial ecosystem that resides within the mammalian intestine and in other mucosal surfaces.
This microbial community is dominated by bacteria, but also includes archaea, eukarya and viruses. The Elinav group aims to decode how the vast microbiome repertoire functions in ways that benefit the host. The gut microbiome is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche, and multiple environmental factors such as our nutritional repertoire and bio-geographical location. The mucosal immune system, as one example, co-evolves with the microbiome from birth, and intimately interacts with it through multiple mechanisms that remain elusive to date. Importantly, it has been recently highlighted that dysregulation of a number of genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing the host to diseases including chronic inflammation, obesity, the metabolic syndrome and cancer.
The Elinav lab has identified various important mechanisms that participate in the reciprocal regulation between the host and the intestinal microbiome, and has demonstrated that disruption of these factors leads to dysbiosis and susceptibility to common multi-factorial disease in mice and humans both. Understanding the molecular basis of host-microbiome interactions may lead to the development of new microbiome-targeting treatments.
Awards
Levinson Award, 2016
Lindner Award, 2016
Rappaport Prize for Biomedical Research, 2015
Alon Award, 2013
This microbial community is dominated by bacteria, but also includes archaea, eukarya and viruses. The Elinav group aims to decode how the vast microbiome repertoire functions in ways that benefit the host. The gut microbiome is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche, and multiple environmental factors such as our nutritional repertoire and bio-geographical location. The mucosal immune system, as one example, co-evolves with the microbiome from birth, and intimately interacts with it through multiple mechanisms that remain elusive to date. Importantly, it has been recently highlighted that dysregulation of a number of genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing the host to diseases including chronic inflammation, obesity, the metabolic syndrome and cancer.
The Elinav lab has identified various important mechanisms that participate in the reciprocal regulation between the host and the intestinal microbiome, and has demonstrated that disruption of these factors leads to dysbiosis and susceptibility to common multi-factorial disease in mice and humans both. Understanding the molecular basis of host-microbiome interactions may lead to the development of new microbiome-targeting treatments.
Awards
Levinson Award, 2016
Lindner Award, 2016
Rappaport Prize for Biomedical Research, 2015
Alon Award, 2013
研究兴趣
论文共 360 篇作者统计合作学者相似作者
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Dermatologyno. 3 (2024): 443-452
Rishika Prasad, Abdur Rehman,Lubna Rehman,Faezeh Darbaniyan,Viktoria Blumenberg,Maria-Luisa Schubert,Uria Mor,Eli Zamir,Sabine Schmidt,Tomo Hayase,Chang Chia-Chi, Lauren Kelley McDaniel,Ivonne Flores,Paolo Strati,Ranjit Nair,Dai Chihara,Luis E Fayad,Sairah Ahmed,Swaminathan P Iyer,Michael L Wang,Preetesh Jain,Loretta J Nastoupil,Jason R Westin,Reetakshi Arora,Joel Gordon Turner,Fareed Khawaja,Ranran Wu,Jennifer B Dennison,Meghan Menges, Melanie Hidalgo-Vargas,Kayla M Reid, Marco L Davila,Peter Dreger,Felix Korell,Anita Schmitt,Mark R Tanner,Richard E Champlin,Christopher R Flowers,Elizabeth J Shpall,Samir Hanash,Sattva S Neelapu,Michael Schmitt,Marion Subklewe,Johannes Fahrmann, Christoph Stein-Thoeringer,Eran Elinav, Michael D Jain,Eiko Hayase,Robert R Jenq,Neeraj Y Saini
Blood (2024)
Tzipi Braun,Rui Feng,Amnon Amir,Nina Levhar,Hila Shacham,Ren Mao,Rotem Hadar, Itamar Toren,Yadid Algavi,Kathleen Abu-Saad, Shuoyu Zhuo,Gilat Efroni,Alona Malik,Orit Picard,Miri Yavzori,Bella Agranovich,Ta-Chiang Liu,Thaddeus S. Stappenbeck,Lee Denson,Ofra Kalter-Leibovici,Eyal Gottlieb,Elhanan Borenstein,Eran Elinav,Minhu Chen,Shomron Ben-Horin,Yael Haberman
Nature Communicationsno. 1 (2024)
Svenja Schuehle,Eleni Kotsiliti,Yotam Cohen, Sisi Deng, Hélčne Omer, Feng Han,Mengjie Qiu, Aysan Poursadegh Zonouzi,Sabine Schmidt,Jose Efren Barragan Avila,Mirian Fernández Vaquero,Enrico Focaccia,Sandra Prokosch,Ulrike Rothermel,Florian Müller,Jenny Hetzer,Danijela Heide, Lukas Mager, Daniele Bucci,Ari Waisman,Christoph Trautwein,Dirk Haller,Eran Elinav,Mathias Heikenwälder
Journal of Hepatology (2024)
Current Opinion in Immunology (2024): 102471
CELL RESEARCHno. 7 (2024): 469-470
Thomas C. G. Bosch,Mark Wigley,Beatriz Colomina,Brendan Bohannan,Forrest Meggers,Katherine R. Amato,Meghan B. Azad,Martin J. Blaser, Kate Brown,Maria Gloria Dominguez-Bello,Stanislav Dusko Ehrlich,Eran Elinav,B. Brett Finlay, Kate Geddie,Naama Geva-Zatorsky,Tamara Giles-Vernick,Philippe Gros,Karen Guillemin,Louis Patrick Haraoui,Elizabeth Johnson,Frederic Keck,Jamie Lorimer,Margaret J. McFall-Ngai,Mark Nichter,Sven Pettersson,Hendrik Poinar,Tobias Rees,Carolina Tropini, Eduardo A. Undurraga,Liping Zhao,Melissa K. Melby
Omer Bar Ziv,Avivit Cahn, Tallulah Jansen,Valery Istomin,Eynat Kedem,Karen Olshtain-Pops,Sarah Israel,Yonatan Oster,Efrat Orenbuch-Harroch,Maya Korem,Jacob Strahilevitz,Itzchak Levy,Rafael Valdes-Mas, Valeria Ivanova,Eran Elinav,Eduardo Shahar,Hila Elinav
JOURNAL OF INFECTIOUS DISEASESno. 2 (2024): 411-420
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作者统计
#Papers: 360
#Citation: 43426
H-Index: 85
G-Index: 208
Sociability: 7
Diversity: 3
Activity: 541
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