We explore if epigenetics is a hallmark of protein-based inheritance in neurodegeneration. Our research specifically investigates epigenetic mechanisms in human prion diseases. We employ a large array of technologies (transcriptomics, epigenomics, cell-based assays, animal models, patients samples) to determine if, where, when and how epigenetics contribute to disease susceptibility, onset, and progression. Using next-generation technologies we profile DNA, RNA, and histone modifications and identify disease-specific gene (coding and non-coding) signatures and pathways. Some of our current projects also involve machine learning, nanopore sequencing, small molecule inhibitor and genome editing.

Ultimately, our research aims to uncover protein-based inheritance signatures that could be manipulated through drugs and/or lifestyle changes.