Her research interest includes phase I/II clinical trials and epidemiologic studies in retinovascular diseases such as age-related macular degeneration, diabetic retinopathy, and other ocular diseases. She has worked extensively in large multi-centered trials headed by the staff from her division, including the Early Treatment Diabetic Retinopathy Study (ETDRS), the Age-Related Eye Disease Study (AREDS) and the Age-Related Eye Disease Study 2 (AREDS2), which she chairs. She works on other clinical trials in collaboration with other institutes within NIH such as the Actions to Control Cardiovascular Risk in Diabetes (ACCORD) Trial and she chairs the ACCORD Eye Study. She directs the clinical portion of the international study, Macular Telangiectasia Project.